DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Gwang-Noh | - |
dc.contributor.author | Yu, Taejong | - |
dc.contributor.author | Lee, Hyune-Jea | - |
dc.contributor.author | Gyak, Ki-Won | - |
dc.contributor.author | Kang, Ji-Ho | - |
dc.contributor.author | You, Donghyun | - |
dc.contributor.author | Kim, Dong-Pyo | - |
dc.date.accessioned | 2019-12-03T12:50:35Z | - |
dc.date.available | 2019-12-03T12:50:35Z | - |
dc.date.created | 2019-11-06 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1473-0197 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/100218 | - |
dc.description.abstract | Microreactors are emerging as an efficient, sustainable synthetic tool compared to conventional batch reactors. Here, we present a new numbering-up metal microreactor by integrating a flow distributor and a copper catalytic module for high productivity of a commercial synthetic drug. A flow distributor and an embedded baffle disc were manufactured by CNC machining and 3D printing of stainless steel (S/S), respectively, whereas a catalytic reaction module was composed of 25 copper coiled capillaries configured in parallel. Eventually, the numbering-up microreactor system assembled with functional modules showed uniform flow distribution and high mixing efficiency regardless of clogging, and achieved high-throughput synthesis of the drug "rufinamide", an anticonvulsant medicine, via a Cu(i)-catalyzed azide-alkyne cycloaddition reaction under optimized conditions. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | LAB ON A CHIP | - |
dc.title | A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/c9lc00764d | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | LAB ON A CHIP, v.19, no.20, pp.3535 - 3542 | - |
dc.identifier.wosid | 000490548200014 | - |
dc.citation.endPage | 3542 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 3535 | - |
dc.citation.title | LAB ON A CHIP | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Ahn, Gwang-Noh | - |
dc.contributor.affiliatedAuthor | Yu, Taejong | - |
dc.contributor.affiliatedAuthor | Lee, Hyune-Jea | - |
dc.contributor.affiliatedAuthor | Gyak, Ki-Won | - |
dc.contributor.affiliatedAuthor | Kang, Ji-Ho | - |
dc.contributor.affiliatedAuthor | You, Donghyun | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Pyo | - |
dc.identifier.scopusid | 2-s2.0-85073080763 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FLOW CHEMISTRY | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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