Mussel-inspired enzyme immobilization and dual real-time compensation algorithms for durable and accurate continuous glucose monitoring
SCIE
SCOPUS
- Title
- Mussel-inspired enzyme immobilization and dual real-time compensation algorithms for durable and accurate continuous glucose monitoring
- Authors
- Kim, K.B.; Choi, H.; Jung, H.J.; Oh, Y.-J.; Cho, C.-H.; Min, J.H.; Yoon, S.; Kim, J.; Cho, S.J.; Cha, H.J.
- Date Issued
- 2019-10
- Publisher
- ELSEVIER ADVANCED TECHNOLOGY
- Abstract
- Blood glucose sensing is very important for diabetic management. It is shifting towards a continuous glucose monitoring because such a system can alleviate patient suffering and provide a large number of glucose measurements. Here, we proposed a novel approach for the development of durable and accurate enzymatic continuous glucose monitoring system (CGMS). For the long-term durable and selective immobilization of glucose oxidase on a microneedle electrode, a biocompatible engineered mussel adhesive protein was employed through efficient electrochemical oxidation strategy. For the accurate performance in in vivo environments, we also suggested dual real-time compensated algorithms to cover both temperature and time-lag differences. After pre-clinical and pilot-clinical evaluations, we confirmed that our proposed CGMS has an outstanding performance compared with various commercially available continuous systems and achieves comparable performance to disposable glucose sensors.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/100220
- DOI
- 10.1016/j.bios.2019.111622
- ISSN
- 0956-5663
- Article Type
- Article
- Citation
- BIOSENSORS & BIOELECTRONICS, vol. 143, 2019-10
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- There are no files associated with this item.
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