DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li Meng | - |
dc.contributor.author | SUNGWAN, KIM | - |
dc.contributor.author | ARA, LEE | - |
dc.contributor.author | Shrinidhi Annadka | - |
dc.contributor.author | Young Ho, Ko | - |
dc.contributor.author | LIM, HAEGYUN | - |
dc.contributor.author | KIM, HYUNG HAM | - |
dc.contributor.author | Park, Kyeung Min | - |
dc.contributor.author | KIM, KIMOON | - |
dc.date.accessioned | 2019-12-06T06:30:14Z | - |
dc.date.available | 2019-12-06T06:30:14Z | - |
dc.date.created | 2019-12-04 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/100435 | - |
dc.description.abstract | Here, we demonstrate a supramolecular latching tool for bio-orthogonal noncovalent anchoring of small synthetic molecules in live animal models using a fully synthetic high-affinity binding pair between cucurbit[7]uril (CB[7]) and adamantylammonium (AdA). This supramolecular latching system is small (similar to 1 kDa), ensuring efficient uptake into cells, tissues, and whole organisms. It is also chemically robust and resistant to enzymatic degradation and analogous to well-characterized biological systems in terms of noncovalent binding. Occurrence of fluorescence resonance energy transfer (FRET) between cyanine 3-CB[7] (Cy3-CB[7]) and boron-dipyrromethene 630/650X-AdA (BDP630/650-AdA) inside a live worm (Caenorhabditis elegans) indicates efficient in situ high-affinity association between AdA and CB[7] inside live animals. In addition, selective visualization of a cancer site of a live mouse upon supramolecular latching of cyanine 5-AdA (Cy5-AdA) on prelocalized CB[7]-conjugating antibody on the cancer site demonstrates the potential of this synthetic system for in vivo cancer imaging. These findings provide a fresh insight into the development of new chemical biology tools and medical therapeutic systems. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.title | Bio-orthogonal Supramolecular Latching inside Live Animals and Its Application for in Vivo Cancer Imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acsami.9b16283 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.11, no.47, pp.43920 - 43927 | - |
dc.identifier.wosid | 000500415700011 | - |
dc.citation.endPage | 43927 | - |
dc.citation.number | 47 | - |
dc.citation.startPage | 43920 | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | SUNGWAN, KIM | - |
dc.contributor.affiliatedAuthor | ARA, LEE | - |
dc.contributor.affiliatedAuthor | LIM, HAEGYUN | - |
dc.contributor.affiliatedAuthor | KIM, HYUNG HAM | - |
dc.contributor.affiliatedAuthor | KIM, KIMOON | - |
dc.identifier.scopusid | 2-s2.0-85075738008 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | bioimaging | - |
dc.subject.keywordPlus | host-guest chemistry | - |
dc.subject.keywordPlus | molecular recognition | - |
dc.subject.keywordPlus | cucurbituril | - |
dc.subject.keywordPlus | synthetic binding pair | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
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