DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HY | - |
dc.contributor.author | Kang, HK | - |
dc.contributor.author | Jo, EJ | - |
dc.contributor.author | Kim, JI | - |
dc.contributor.author | Lee, YN | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Park, YM | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Kwak, JY | - |
dc.contributor.author | Bae, YS | - |
dc.date.accessioned | 2015-06-25T01:55:28Z | - |
dc.date.available | 2015-06-25T01:55:28Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2004-04-30 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.other | 2015-OAK-0000004268 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10191 | - |
dc.description.abstract | Dendritic cells (DCs) play a key role in activating the immune response against invading pathogens as well as dying cells or tumors. Although the immune response can be initiated by the phagocytic activity by DCs, the molecular mechanism involved in this process has not been fully investigated. Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) stimulates the activation of phospholipase D (PLD) via Ca2+ increase and protein kinase C activation in mouse DC cell line, DC2.4. WKYMVM stimulates the phagocytic activity, which is inhibited in the presence of N-butanol but not t-butanol in DC2.4 cells. Furthermore, the addition of phosphatidic acid, an enzymatic product of PLD activity, enhanced the phagocytic activity in DC2.4 cells. Since at least two of formyl peptide receptor (FPR) family (FPR1 and FPR2) are expressed in DC2.4 as well as in mouse bone marrow-derived dendritic cells, this study suggests that the activation of FPR family by WKYMVM stimulates the PLD activity resulting in phagocytic activity in DC2.4 cells. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Trp-Lys-Tyr-Met-Val-Met stimulates phagocytosis via phospholipase D-dependent signaling in mouse dendritic cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1038/emm.2004.20 | - |
dc.author.google | Lee, HY | en_US |
dc.author.google | Kang, HK | en_US |
dc.author.google | Bae, YS | en_US |
dc.author.google | Kwak, JY | en_US |
dc.author.google | Ryu, SH | en_US |
dc.author.google | Park, YM | en_US |
dc.author.google | Lee, SH | en_US |
dc.author.google | Lee, YN | en_US |
dc.author.google | Kim, JI | en_US |
dc.author.google | Jo, EJ | en_US |
dc.relation.volume | 36 | en_US |
dc.relation.issue | 2 | en_US |
dc.relation.startpage | 135 | en_US |
dc.relation.lastpage | 144 | en_US |
dc.contributor.id | 10069853 | en_US |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.36, no.2, pp.135 - 144 | - |
dc.identifier.wosid | 000221533900006 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 144 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 135 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 36 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-2442703074 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FORMYL PEPTIDE RECEPTOR | - |
dc.subject.keywordPlus | N-FORMYLPEPTIDE RECEPTOR | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | SUPEROXIDE GENERATION | - |
dc.subject.keywordPlus | CHEMOTACTIC AGONIST | - |
dc.subject.keywordPlus | HUMAN NEUTROPHILS | - |
dc.subject.keywordPlus | D ACTIVATION | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDE HYDROLYSIS | - |
dc.subject.keywordPlus | OPSONIZED PARTICLES | - |
dc.subject.keywordPlus | HUMAN MONOCYTES | - |
dc.subject.keywordAuthor | chemotactic factors | - |
dc.subject.keywordAuthor | dendritic cell | - |
dc.subject.keywordAuthor | N-formylmethionine | - |
dc.subject.keywordAuthor | leucyl-phenylalamine | - |
dc.subject.keywordAuthor | oligopeptides | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.subject.keywordAuthor | phospholipase D | - |
dc.subject.keywordAuthor | receptors | - |
dc.subject.keywordAuthor | formyl peptid | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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