DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, JW | - |
dc.contributor.author | Kim, TD | - |
dc.contributor.author | Hong, BS | - |
dc.contributor.author | Kim, OY | - |
dc.contributor.author | Yoon, WH | - |
dc.contributor.author | Chae, CB | - |
dc.contributor.author | Gho, YS | - |
dc.date.accessioned | 2015-06-25T01:56:06Z | - |
dc.date.available | 2015-06-25T01:56:06Z | - |
dc.date.created | 2013-11-01 | - |
dc.date.issued | 2010-07-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.other | 2015-OAK-0000021845 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10201 | - |
dc.description.abstract | Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for anti-cancer therapy. Previously, we reported that a hexapeptide (RRKRRR, RK6) blocked the growth and metastasis of tumor by inhibiting VEGF binding to its receptors. In addition, dRK6, the D-form derivative of RK6, retained its biological activity with improved serum stability. In the present study, we developed a serum-stable branched dimeric peptide (MAP2-dRK6) with enhanced anti-VEGF and anti-tumor activity. MAP2-dRK6 is more effective than dRK6 in many respects: inhibition of VEGF binding to its receptors, VEGF- and tumor conditioned medium-induced proliferation and ERK signaling of endothelial cells, and VEGF-induced migration and tube formation of endothelial cells. Moreover, MAP2-dRK6 blocks in vivo growth of VEGF-secreting colorectal cancer cells by the suppression of angiogenesis and the subsequent induction of tumor cell apoptosis. Our observations suggest that MAP2-dRK6 can be a prospective therapeutic molecule or lead compound for the development of drugs for various VEGF-related angiogenic diseases. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.3858/EMM.2010.42.7.052 | - |
dc.author.google | Kim, JW | en_US |
dc.author.google | Kim, TD | en_US |
dc.author.google | Gho, YS | en_US |
dc.author.google | Chae, CB | en_US |
dc.author.google | Yoon, WH | en_US |
dc.author.google | Kim, OY | en_US |
dc.author.google | Hong, BS | en_US |
dc.relation.volume | 42 | en_US |
dc.relation.issue | 7 | en_US |
dc.relation.startpage | 514 | en_US |
dc.relation.lastpage | 523 | en_US |
dc.contributor.id | 10138843 | en_US |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.42, no.7, pp.514 - 523 | - |
dc.identifier.wosid | 000280558100004 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 523 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 514 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 42 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-77955836645 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.description.scptc | 5 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | VASCULAR-PERMEABILITY FACTOR | - |
dc.subject.keywordPlus | RECEPTOR-BINDING SITE | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | ARG YIGSR | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | angiogenesis inhibitors | - |
dc.subject.keywordAuthor | colorectal neoplasms | - |
dc.subject.keywordAuthor | peptides | - |
dc.subject.keywordAuthor | receptors | - |
dc.subject.keywordAuthor | vascular endothelial growth factor | - |
dc.subject.keywordAuthor | vascular endothelial growth factors | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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