DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, SJ | - |
dc.contributor.author | Park, JS | - |
dc.contributor.author | Heo, YJ | - |
dc.contributor.author | Kang, CM | - |
dc.contributor.author | Kim, EK | - |
dc.contributor.author | Lim, MA | - |
dc.contributor.author | Ryu, JG | - |
dc.contributor.author | Park, SJ | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Kim, HY | - |
dc.contributor.author | Min, JK | - |
dc.contributor.author | Cho, ML | - |
dc.date.accessioned | 2015-06-25T01:56:28Z | - |
dc.date.available | 2015-06-25T01:56:28Z | - |
dc.date.created | 2015-02-04 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.other | 2015-OAK-0000030973 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10207 | - |
dc.description.abstract | Interleukin (IL)-27 is a novel cytokine of the IL-6/IL-12 family that has been reported to be involved in the pathogenesis of autoimmune diseases and has a pivotal role as both a pro-and anti-inflammatory cytokine. We investigated the in vivo effects of IL-27 on arthritis severity in a murine collagen-induced arthritis (CIA) model and its mechanism of action regarding control of regulatory T (Tregs) and IL-17-producing T helper 17 (Th17) cells. IL-27-Fc-treated CIA mice showed a lower severity of arthritis. IL-17 expression in the spleens was significantly decreased in IL-27-Fc-treated CIA mice compared with that in the CIA model. The Th17 population was decreased in the spleens of IL-27-Fc-treated CIA mice, whereas the CD4(+)CD25(+)Foxp(3+) Treg population increased. In vitro studies revealed that IL-27 inhibited IL-17 production in murine CD4(+) T cells, and the effect was associated with retinoic acid-related orphan receptor gamma T and signal transducer and activator of transcription 3 inhibition. In contrast, fluorescein isothiocyanate-labeled forkhead box P3 (Foxp3) and IL-10 were profoundly augmented by IL-27 treatment. Regarding the suppressive capacity of Treg cells, the proportions of CTLA-4(+) (cytotoxic T-lymphocyte antigen 4), PD-1(+) (programmed cell death protein 1) and GITR(+) (glucocorticoid-induced tumor necrosis factor receptor) Tregs increased in the spleens of IL-27-Fc-treated CIA mice. Furthermore, in vitro differentiated Treg cells with IL-27 exerted a more suppressive capacity on T-cell proliferation. We found that IL-27 acts as a reciprocal regulator of the Th17 and Treg populations in CD4(+) cells isolated from healthy human peripheral blood mononuclear cells (PBMCs), as well as from humans with rheumatoid arthritis (RA) PBMCs. Our study suggests that IL-27 has the potential to ameliorate overwhelming inflammation in patients with RA through a reciprocal regulation of Th17 and Treg cells. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.subject | collagen-induced arthritis | - |
dc.subject | interleukin-27 | - |
dc.subject | interleukin-17-producing T cells | - |
dc.subject | regulatory T cells | - |
dc.subject | rheumatoid arthritis | - |
dc.subject | TNF-ALPHA THERAPY | - |
dc.subject | PATHOGENIC T-CELL | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | DESTRUCTIVE ARTHRITIS | - |
dc.subject | TGF-BETA | - |
dc.subject | AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | SYNOVIAL-FLUID | - |
dc.subject | ANIMAL-MODELS | - |
dc.subject | INFLAMMATION | - |
dc.title | In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1038/EMM.2013.89 | - |
dc.author.google | Moon, SJ | en_US |
dc.author.google | Park, JS | en_US |
dc.author.google | Cho, ML | en_US |
dc.author.google | Min, JK | en_US |
dc.author.google | Kim, HY | en_US |
dc.author.google | Park, SH | en_US |
dc.author.google | Sung, YC | en_US |
dc.author.google | Park, KS | en_US |
dc.author.google | Park, SJ | en_US |
dc.author.google | Ryu, JG | en_US |
dc.author.google | Lim, MA | en_US |
dc.author.google | Kim, EK | en_US |
dc.author.google | Kang, CM | en_US |
dc.author.google | Heo, YJ | en_US |
dc.relation.volume | 45 | en_US |
dc.contributor.id | 10053752 | en_US |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.45 | - |
dc.identifier.wosid | 000328123500002 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 45 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-84892421982 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 33 | - |
dc.description.scptc | 30 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PATHOGENIC T-CELL | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | DESTRUCTIVE ARTHRITIS | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | DISTINCT | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CTLA-4 | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordAuthor | collagen-induced arthritis | - |
dc.subject.keywordAuthor | interleukin-27 | - |
dc.subject.keywordAuthor | interleukin-17-producing T cells | - |
dc.subject.keywordAuthor | regulatory T cells | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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