DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung Eun | - |
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Sharma, Garima | - |
dc.contributor.author | Lee, So Young | - |
dc.contributor.author | Shin, Hee Soon | - |
dc.contributor.author | Rudra, Dipayan | - |
dc.contributor.author | Im, Sin-Hyeog | - |
dc.date.accessioned | 2020-05-04T09:50:21Z | - |
dc.date.available | 2020-05-04T09:50:21Z | - |
dc.date.created | 2020-01-22 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/103624 | - |
dc.description.abstract | Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify immunostimulatory and immunoregulatory microbes is needed. Here, we successfully established an in vitro screening system and identified an immunoregulatory bacterium, Lactobacillus pentosus KF340 (LP340), present in various fermented foods. LP340 induced a regulatory phenotype in mice Ag presenting cells which, in turn, induced IL-10 and IFNI producing Type 1 regulatory T cells (Tr1 cells) from naive CDC T cells. Naive CD4* T cells co-cultured with LP340 treated dendritic cells highly expressed cytokine receptor IL-27R and were CD49b and lymphocyte-activation gene 3 double positive. Oral administration of LP340 in mice with atopic dermatitis reduced cellular infiltration in affected ear lobes and serum IgE levels, thus, ameliorating the disease symptoms. This suggests a systemic immunoregulatory effect of LP340. These findings demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells. | - |
dc.language | English | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.title | Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.4110/in.2019.19.e39 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, v.19, no.6 | - |
dc.identifier.kciid | ART002546185 | - |
dc.identifier.wosid | 000505714300003 | - |
dc.citation.number | 6 | - |
dc.citation.title | IMMUNE NETWORK | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Sharma, Amit | - |
dc.contributor.affiliatedAuthor | Sharma, Garima | - |
dc.contributor.affiliatedAuthor | Rudra, Dipayan | - |
dc.contributor.affiliatedAuthor | Im, Sin-Hyeog | - |
dc.identifier.scopusid | 2-s2.0-85078736633 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | MICROBIOTA | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | Tr1 cells | - |
dc.subject.keywordAuthor | Lactobacillus pentosus | - |
dc.subject.keywordAuthor | Interleukin-10 | - |
dc.subject.keywordAuthor | IL-10 | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Immunology | - |
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