Open Access System for Information Sharing

Login Library

 

Conference
Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads
Full metadata record
Files in This Item:
There are no files associated with this item.
DC FieldValueLanguage
dc.contributor.authorNageswarran, Dyvyashree C-
dc.contributor.author김재일-
dc.contributor.authorLambing, Christophe-
dc.contributor.author김주현-
dc.contributor.author박지혜-
dc.contributor.author김언정-
dc.contributor.author조현섭-
dc.contributor.author김희진-
dc.contributor.author변도환-
dc.contributor.author박영미-
dc.contributor.author이승철-
dc.contributor.authorTock, Andy-
dc.contributor.author황일두-
dc.contributor.authorZhao, Xiaohui-
dc.contributor.authorHenderson, Ian R-
dc.contributor.author최규하-
dc.date.accessioned2020-11-13T00:52:07Z-
dc.date.available2020-11-13T00:52:07Z-
dc.date.created2020-09-23-
dc.date.issued2020-08-18-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/104301-
dc.description.abstractMeiotic crossover creates new combinations of genetic variation and ensures balanced chromosome transmission. Crossover numbers per meiosis are tightly restricted in most eukaryotes, despite a large excess of initiating DNA double-strand break precursors. The majority of crossovers in plants are dependent on the Class I interfering repair pathway. A minority of crossovers are formed by the Class II non-interfering pathway, which is normally limited by multiple anti-recombination pathways. However, similar pathways that limit Class I interfering crossovers are unknown. To identify regulators of crossover formation, we performed a forward genetic screen in Arabidopsis using fluorescent crossover reporters, to identify mutants with increased or decreased recombination frequency. This screen identified the HIGH CROSSOVER RATE1 (HCR1) gene as repressing crossovers. Using genome-wide analysis we show that hcr1 crossovers are most strongly increased in the distal euchromatic chromosome arms. We observe a significant increase in MLH1 foci in hcr1 and a decrease in the strength of crossover interference, which is consistent with a major effect on the Class I pathway. We used yeast two hybrid and in planta assays to demonstrate physical interaction between HCR1 and multiple proteins within the Class I interfering pathway, including HEI10, PTD, and MSH5. Our data identify HCR1 as limiting the number of interfering Class I crossovers in plants. We propose that HCR1 acts in opposition to pro-recombination DNA repair or cell division kinases, in order to limit crossover number per meiosis.-
dc.languageEnglish-
dc.publisher사단법인 한국육종학회, SABRAO-
dc.relation.isPartOf2020년 한국육종학회 국제공동학술발표회-
dc.relation.isPartOf유전체기반 디지털육종의 연구와 실용화전략 (Digital Breeding Based on Genomics)-
dc.titleHIGH CROSSOVER RATE1 restricts the number of meiotic crossovers in Arabidopsis-
dc.typeConference-
dc.type.rimsCONF-
dc.identifier.bibliographicCitation2020년 한국육종학회 국제공동학술발표회-
dc.citation.conferenceDate2020-08-18-
dc.citation.conferencePlaceKO-
dc.citation.title2020년 한국육종학회 국제공동학술발표회-
dc.contributor.affiliatedAuthor김재일-
dc.contributor.affiliatedAuthor김주현-
dc.contributor.affiliatedAuthor박지혜-
dc.contributor.affiliatedAuthor김언정-
dc.contributor.affiliatedAuthor조현섭-
dc.contributor.affiliatedAuthor김희진-
dc.contributor.affiliatedAuthor변도환-
dc.contributor.affiliatedAuthor박영미-
dc.contributor.affiliatedAuthor이승철-
dc.contributor.affiliatedAuthor황일두-
dc.contributor.affiliatedAuthor최규하-
dc.description.journalClass1-
dc.description.journalClass1-

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

황일두HWANG, IL DOO
Dept of Life Sciences
Read more

Views & Downloads

Browse