DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Inho | - |
dc.contributor.author | London, James | - |
dc.contributor.author | Martin-Lopez, Juana | - |
dc.contributor.author | Liu, Jiaquan | - |
dc.contributor.author | LEE, JONG-BONG | - |
dc.contributor.author | Fishel, Richard | - |
dc.date.accessioned | 2021-06-01T01:58:45Z | - |
dc.date.available | 2021-06-01T01:58:45Z | - |
dc.date.created | 2021-03-07 | - |
dc.date.issued | 2021-03-02 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/105134 | - |
dc.description.abstract | The pathogenic consequences of 369 unique human HsMLH1 missense variants has been hampered by the lack of a detailed function in mismatch repair (MMR). Here single-molecule images show that HsMSH2-HsMSH6 provides a platform for HsMLH1-HsPMS2 to form a stable sliding clamp on mismatched DNA. The mechanics of sliding clamp progression solves a significant operational puzzle in MMR and provides explicit predictions for the distribution of clinically relevant HsMLH1 missense mutations. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.subject | ESCHERICHIA-COLI MUTS | - |
dc.subject | DIFFUSION | - |
dc.title | Linker domain function predicts pathogenic MLH1 missense variants | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.2019215118 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.118, no.9 | - |
dc.identifier.wosid | 000625304300038 | - |
dc.citation.number | 9 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 118 | - |
dc.contributor.affiliatedAuthor | Yang, Inho | - |
dc.contributor.affiliatedAuthor | LEE, JONG-BONG | - |
dc.identifier.scopusid | 2-s2.0-85101641965 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | mismatch repair | - |
dc.subject.keywordAuthor | Lynch syndrome | - |
dc.subject.keywordAuthor | HNPCC | - |
dc.subject.keywordAuthor | single molecule | - |
dc.subject.keywordAuthor | sliding clamp | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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