DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rak Kwon D. | - |
dc.contributor.author | Jung S. | - |
dc.contributor.author | Jang J. | - |
dc.contributor.author | Park G.-Y. | - |
dc.contributor.author | Suk Moon Y. | - |
dc.contributor.author | Lee S.C. | - |
dc.date.accessioned | 2021-06-01T02:20:03Z | - |
dc.date.available | 2021-06-01T02:20:03Z | - |
dc.date.created | 2020-05-12 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0363-5465 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/105226 | - |
dc.description.abstract | Background: Chronic full-thickness rotator cuff tears (FTRCTs) represent a major clinical concern because they show highly compromised healing capacity. Purpose: To evaluate the efficacy of using a 3-dimensional (3D) bioprinted scaffold with human umbilical cord blood (hUCB)-mesenchymal stem cells (MSCs) for regeneration of chronic FTRCTs in a rabbit model. Study Design: Controlled laboratory study. Methods: A total of 32 rabbits were randomly assigned to 4 treatment groups (n = 8 per group) at 6 weeks after a 5-mm FTRCT was created on the supraspinatus tendon. Group 1 (G1-SAL) was transplanted with normal saline. Group 2 (G2-MSC) was transplanted with hUCB-MSCs (0.2 mL, 1 x 10(6)) into FTRCTs. Group 3 (G3-3D) was transplanted with a 3D bioprinted construct without MSCs, and group 4 (G4-3D+MSC) was transplanted with a 3D bioprinted construct containing hUCB-MSCs (0.2 mL, 1 x 10(6) cells) into FTRCTs. All 32 rabbits were euthanized at 4 weeks after treatment. Examination of gross morphologic changes and histologic results was performed on all rabbits after sacrifice. Motion analysis was also performed before and after treatment. Results: In G4-3D+MSC, newly regenerated collagen type 1 fibers, walking distance, fast walking time, and mean walking speed were greater than those in G2-MSC based on histochemical and motion analyses. In addition, when compared with G3-3D, G4-3D+MSC showed more prominent regenerated tendon fibers and better parameters of motion analysis. However, there was no significant difference in gross tear size among G2-MSC, G3-3D, and G4-3D+MSC, although these groups showed significant decreases in tear size as compared with the control group (G1-SAL). Conclusion: Findings of this study show that a tissue engineering strategy based on a 3D bioprinted scaffold filled with hUCB-MSCs can improve the microenvironment for regenerative processes of FTRCT without any surgical repair. | - |
dc.language | English | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF SPORTS MEDICINE | - |
dc.title | A 3-Dimensional Bioprinted Scaffold With Human Umbilical Cord Blood-Mesenchymal Stem Cells Improves Regeneration of Chronic Full-Thickness Rotator Cuff Tear in a Rabbit Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/0363546520904022 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF SPORTS MEDICINE, v.48, no.4, pp.947 - 958 | - |
dc.identifier.wosid | 000523849900019 | - |
dc.citation.endPage | 958 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 947 | - |
dc.citation.title | AMERICAN JOURNAL OF SPORTS MEDICINE | - |
dc.citation.volume | 48 | - |
dc.contributor.affiliatedAuthor | Jung S. | - |
dc.contributor.affiliatedAuthor | Jang J. | - |
dc.identifier.scopusid | 2-s2.0-85081745895 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | rotator cuff | - |
dc.subject.keywordAuthor | scaffold | - |
dc.subject.keywordAuthor | shoulder | - |
dc.subject.keywordAuthor | tissue engineering | - |
dc.subject.keywordAuthor | 3D cell-printed construct | - |
dc.relation.journalWebOfScienceCategory | Orthopedics | - |
dc.relation.journalWebOfScienceCategory | Sport Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Orthopedics | - |
dc.relation.journalResearchArea | Sport Sciences | - |
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