Development of mechanically enhanced kagome-structure scaffold for bone regeneration

Abstract

For bone reconstruction, a 3D scaffold has been developed by a variety of materials and structures. However, their material properties were not enough compared to that of the real bone tissue. To enhance mechanical properties of 3D scaffold as a structural approach, we developed a polycaprolactone scaffold with a 3D kagome structure by precision extruding deposition (PED) technique. The developed kagome-structure scaffold was compared with conventional grid-structure scaffold. Their mechanical properties were evaluated by both numerical and experimental analysis. In addition, their biological analysis was carried out by using rabbit calvarial defect model for 16 weeks.