Open Access System for Information Sharing

Login Library

 

Article
Cited 40 time in webofscience Cited 44 time in scopus
Metadata Downloads

3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair SCIE SCOPUS

Title
3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair
Authors
CHAE, SUHUNSUN, YUCHENGCHOI, YEONGJINHA, DONG HEONJEON, INHOCHO, DONG WOO
Date Issued
2021-07
Publisher
IOP PUBLISHING LTD
Abstract
The tendon-bone interface (TBI) in rotator cuffs exhibits a structural and compositional gradient integrated through the fibrocartilaginous transition. Owing to restricted healing capacity, functional regeneration of the TBI is considered a great clinical challenge. Here, we establish a novel therapeutic platform based on 3D cell-printing and tissue-specific bioinks to achieve spatially-graded physiology for functional TBI regeneration. The 3D cell-printed TBI patch constructs are created via a spatial arrangement of cell-laden tendon and bone-specific bioinks in a graded manner, approximating a multi-tissue fibrocartilaginous interface. This TBI patch offers a cell favorable microenvironment, including high cell viability, proliferative capacity, and zonal-specific differentiation of encapsulated stem cells for TBI formation in vitro. Furthermore, in vivo application of spatially-graded TBI patches with stem cells demonstrates their regenerative potential, indicating that repair with 3D cell-printed TBI patch significantly accelerates and promotes TBI healing in a rat chronic tear model. Therefore, our findings propose a new therapeutic strategy for functional TBI regeneration using 3D cell-printing and tissue-specific decellularized extracellular matrix bioink-based approach.
URI
https://oasis.postech.ac.kr/handle/2014.oak/106727
DOI
10.1088/1758-5090/abd159
ISSN
1758-5082
Article Type
Article
Citation
BIOFABRICATION, vol. 13, no. 3, 2021-07
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

조동우CHO, DONG WOO
Dept of Mechanical Enginrg
Read more

Views & Downloads

Browse