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Cited 146 time in webofscience Cited 155 time in scopus
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Structural and functional diversity calls for a new classification of ABC transporters SCIE SCOPUS

Title
Structural and functional diversity calls for a new classification of ABC transporters
Authors
Thomas, ChristophAller, Stephen G.Beis, KonstantinosCarpenter, Elisabeth P.Chang, GeoffreyChen, LeiDassa, ElieDean, MichaelDuong Van Hoa, FranckEkiert, DamianFord, RobertGaudet, RachelleGong, XinHolland, I. BarryHuang, YihuaKahne, Daniel K.Kato, HiroakiKoronakis, VassilisKoth, Christopher M.Lee, YoungsookLewinson, OdedLill, RolandMartinoia, EnricoMurakami, SatoshiPinkett, Heather W.Poolman, BertRosenbaum, DanielSarkadi, BalazsSchmitt, LutzSchneider, ErwinShi, YigongShyng, Show-LingSlotboom, Dirk J.Tajkhorshid, EmadTieleman, D. PeterUeda, KazumitsuVaradi, AndrasWen, Po-ChaoYan, NiengZhang, PengZheng, HongjinZimmer, JochenTampe, Robert
Date Issued
2020-12
Publisher
WILEY
Abstract
Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.
URI
https://oasis.postech.ac.kr/handle/2014.oak/106895
DOI
10.1002/1873-3468.13935
ISSN
0014-5793
Article Type
Article
Citation
FEBS LETTERS, vol. 594, no. 23, 2020-12
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이영숙LEE, YOUNGSOOK
Dept of Life Sciences
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