DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hur, EM | - |
dc.contributor.author | Park, YS | - |
dc.contributor.author | Huh, YH | - |
dc.contributor.author | Yoo, SH | - |
dc.contributor.author | Woo, KC | - |
dc.contributor.author | Choi, BH | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2015-06-25T02:17:47Z | - |
dc.date.available | 2015-06-25T02:17:47Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2005-05-23 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.other | 2015-OAK-0000005134 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10690 | - |
dc.description.abstract | Ca2+ is a highly versatile intracellular signal that regulates many different cellular processes, and cells have developed mechanisms to have exquisite control over Ca2+ signaling. Epidermal growth factor ( EGF), which fails to mobilize intracellular Ca2+ when administrated alone, becomes capable of evoking [Ca2+](i) increase and exocytosis after bradykinin (BK) stimulation in chromaffin cells. Here, we provide evidence that this sensitization process is coordinated by a macromolecular signaling complex comprised of inositol 1,4,5- trisphosphate receptor type I(IP(3)R1), cAMP- dependent protein kinase (PKA), EGF receptor (EGFR), and an A-kinase anchoring protein, yotiao. The IP3R complex functions as a focal point to promote Ca2+ release in two ways: (1) it facilitates PKA-dependent phosphorylation of IP(3)R1 in response to BK-induced elevation of cAMP, and (2) it couples the plasmalemmal EGFR with IP(3)R1 at the Ca2+ store located juxtaposed to the plasma membrane. Our study illustrates how the junctional membrane IP3R complex connects different signaling pathways to define the fidelity and specificity of Ca2+ signaling. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF CELL BIOLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1083/JCB.200411034 | - |
dc.author.google | Hur, EM | en_US |
dc.author.google | Park, YS | en_US |
dc.author.google | Kim, KT | en_US |
dc.author.google | Choi, BH | en_US |
dc.author.google | Woo, KC | en_US |
dc.author.google | Yoo, SH | en_US |
dc.author.google | Huh, YH | en_US |
dc.relation.volume | 169 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.startpage | 657 | en_US |
dc.relation.lastpage | 667 | en_US |
dc.contributor.id | 10104775 | en_US |
dc.relation.journal | JOURNAL OF CELL BIOLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL BIOLOGY, v.169, no.4, pp.657 - 667 | - |
dc.identifier.wosid | 000229305400014 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 667 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 657 | - |
dc.citation.title | JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 169 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-22344432189 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 12 | - |
dc.description.scptc | 13 | * |
dc.date.scptcdate | 2018-06-152 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN-KINASE-A | - |
dc.subject.keywordPlus | EPIDERMAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | POSTTRAUMATIC-STRESS-DISORDER | - |
dc.subject.keywordPlus | IP3 RECEPTORS | - |
dc.subject.keywordPlus | ANCHORING PROTEINS | - |
dc.subject.keywordPlus | CALCIUM SIGNALS | - |
dc.subject.keywordPlus | ACINAR-CELLS | - |
dc.subject.keywordPlus | HOMER BINDS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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