DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hao, Lam Tan | - |
dc.contributor.author | Park, Sohee | - |
dc.contributor.author | Choy, Seunghwan | - |
dc.contributor.author | Kim, Young-Min | - |
dc.contributor.author | Lee, Seung-Woo | - |
dc.contributor.author | Ok, Yong Sik | - |
dc.contributor.author | Koo, Jun Mo | - |
dc.contributor.author | Hwang, Sung Yeon | - |
dc.contributor.author | Hwang, Dong Soo | - |
dc.contributor.author | Park, Jeyoung | - |
dc.contributor.author | Oh, Dongyeop X. | - |
dc.date.accessioned | 2021-10-10T01:50:15Z | - |
dc.date.available | 2021-10-10T01:50:15Z | - |
dc.date.created | 2021-10-06 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2691-3704 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/107244 | - |
dc.description.abstract | Gluing dynamic, wet biological tissue is important in injury treatment yet difficult to achieve. Polymeric adhesives are inconvenient to handle due to rapid cross-linking and can raise biocompatibility concerns. Inorganic nanoparticles adhere weakly to wet surfaces. Herein, an aqueous suspension of guanidinium-functionalized chitin nanoparticles as a biomedical adhesive with biocompatible, hemostatic, and antibacterial properties is developed. It glues porcine skin up to 3000-fold more strongly (30 kPa) than inorganic nanoparticles at the same concentration and adheres at neutral pH, which is unachievable with mussel-inspired adhesives alone. The glue exhibits an instant adhesion (2 min) to fully wet surfaces, and the glued assembly endures one-week underwater immersion. The suspension is lowly viscous and stable, hence sprayable and convenient to store. A nanomechanic study reveals that guanidinium moieties are chaotropic, creating strong, multifaceted noncovalent bonds with proteins: salt bridges comprising ionic attraction and bidentate hydrogen bonding with acidic moieties, cation−π interactions with aromatic moieties, and hydrophobic interactions. The adhesion mechanism provides a blueprint for advanced tissue adhesives. | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | JACS Au | - |
dc.title | Strong, Multifaceted Guanidinium-Based Adhesion of Bioorganic Nanoparticles to Wet Biological Tissue | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/jacsau.1c00193 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JACS Au, v.1, no.9, pp.1399 - 1411 | - |
dc.citation.endPage | 1411 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1399 | - |
dc.citation.title | JACS Au | - |
dc.citation.volume | 1 | - |
dc.contributor.affiliatedAuthor | Park, Sohee | - |
dc.contributor.affiliatedAuthor | Choy, Seunghwan | - |
dc.contributor.affiliatedAuthor | Kim, Young-Min | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Woo | - |
dc.contributor.affiliatedAuthor | Hwang, Dong Soo | - |
dc.contributor.affiliatedAuthor | Park, Jeyoung | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
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