Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with parkinson disease in mammalian cells and drosophila
SCIE
SCOPUS
- Title
- Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with parkinson disease in mammalian cells and drosophila
- Authors
- Song S.; Jang S.; Park J.; Bang S.; Choi S.; Kwon K.-Y.; Zhuang X.; Kim E.; Chung J.
- Date Issued
- 2013-02-22
- Publisher
- American Society for Biochemistry and Molecular Biology Inc.
- Abstract
- Background: Mutations in PINK1 cause recessive Parkinson disease. Results: PINK1 mutations in the kinase domain hamper Parkin translocation to mitochondria, and their analogous mutations in Drosophila cannot rescue PINK1-null phenotypes. Conclusion: PINK1 kinase activity is essential for its function and for regulating Parkin functions in mitochondria. Significance: Understanding the roles of PINK1 mutations will be helpful for deciphering the pathogenic mechanism of PINK1-linked Parkinson disease. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107479
- DOI
- 10.1074/jbc.M112.430801
- ISSN
- 0021-9258
- Article Type
- Article
- Citation
- Journal of Biological Chemistry, vol. 288, no. 8, page. 5660 - 5672, 2013-02-22
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- There are no files associated with this item.
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