DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Eun Na | - |
dc.contributor.author | Kim, Sang Heon | - |
dc.contributor.author | Ko, Young Gun | - |
dc.contributor.author | Kwon, Jae Hyun | - |
dc.contributor.author | HAN, JEONG WOO | - |
dc.contributor.author | Park, In Su | - |
dc.contributor.author | Han, Sung Sik | - |
dc.contributor.author | Kim, Soo Hyun | - |
dc.date.accessioned | 2021-11-20T02:50:03Z | - |
dc.date.available | 2021-11-20T02:50:03Z | - |
dc.date.created | 2021-11-19 | - |
dc.date.issued | 2007-07 | - |
dc.identifier.issn | 1662-9795 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/107514 | - |
dc.description.abstract | A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactideco-epsilon-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinning apparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property, tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffold wasn't fabricated well in the condition of 4% gel concentration. In general, the thickness level of microfibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showed stronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%, 10% and 12.5% scaffolds were analyzed in both directions: circumferential direction and longitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse to examine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds. Both shows very similar degradation rates, but the aspect in tissue in-growth was different. In conclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold for cardiovascular tissue engineering. A tubular and fibrous scaffold was fabricated from an elastic polymer, poly (L-lactideco-epsilon-caprolactone) (PLCL; Mn 193,813, Mw 538,623) 50:50 by using a novel gel spinning apparatus. To characterize the gel-spun scaffold, we investigated morphology, tensile property, tissue in-growth rate and degradation rate. From SEM images, fibrous structure in the scaffold wasn't fabricated well in the condition of 4% gel concentration. In general, the thickness level of microfibers increased as the gel concentration increased. In addition, the gel-spun scaffolds showed stronger tensile properties in the circumferential direction than the longitudinal direction. 5%, 7.5%, 10% and 12.5% scaffolds were analyzed in both directions: circumferential direction and longitudinal direction. On the other hand, the gel-spun scaffolds have been implanted in mouse to examine the degradation rate in vivo and tissue in-growth aspects, compared to extruded scaffolds. Both shows very similar degradation rates, but the aspect in tissue in-growth was different. In conclusion, gel-spun PLCL scaffolds have good characteristics as a plausible scaffold for cardiovascular tissue engineering. | - |
dc.language | English | - |
dc.publisher | Trans Tech Publications, Ltd. | - |
dc.relation.isPartOf | Key Engineering Materials | - |
dc.title | Characterization of the Gel-Spun Tubular Scaffold for Cardiovascular Tissue Engineering | - |
dc.type | Article | - |
dc.identifier.doi | 10.4028/www.scientific.net/kem.342-343.321 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Key Engineering Materials, v.342-343, pp.321 - 324 | - |
dc.identifier.wosid | 000246657900081 | - |
dc.citation.endPage | 324 | - |
dc.citation.startPage | 321 | - |
dc.citation.title | Key Engineering Materials | - |
dc.citation.volume | 342-343 | - |
dc.contributor.affiliatedAuthor | HAN, JEONG WOO | - |
dc.identifier.scopusid | 2-s2.0-34147106629 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Proceedings Paper | - |
dc.subject.keywordAuthor | poly(L-lactide-co-epsilon-caprolactone) (PLCL) | - |
dc.subject.keywordAuthor | Gel spinning fabrcation | - |
dc.subject.keywordAuthor | Bone marrowderived | - |
dc.subject.keywordAuthor | stem cells | - |
dc.subject.keywordAuthor | vascular graft | - |
dc.subject.keywordAuthor | cardiovascular tissue engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Ceramics | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Composites | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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