DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jeong Hun | - |
dc.contributor.author | Ahn, Minjun | - |
dc.contributor.author | Park, Sun Hwa | - |
dc.contributor.author | Kim, Hyeonji | - |
dc.contributor.author | Bae, Mihyeon | - |
dc.contributor.author | Park, Wonbin | - |
dc.contributor.author | Hollister, Scott J. | - |
dc.contributor.author | Kim, Sung Won | - |
dc.contributor.author | Cho, Dong-Woo | - |
dc.date.accessioned | 2021-12-02T08:35:08Z | - |
dc.date.available | 2021-12-02T08:35:08Z | - |
dc.date.created | 2021-11-30 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/107704 | - |
dc.description.abstract | Despite notable advances in extrusion-based 3D bioprinting, it remains a challenge to create a clinically-sized cellular construct using extrusion-based 3D printing due to long printing times adversely affecting cell viability and functionality. Here, we present an advanced extrusion-based 3D bioprinting strategy composed of a two-step printing process to facilitate creation of a trachea-mimetic cellular construct of clinically relevant size. A porous bellows framework is first printed using typical extrusion-based 3D printing. Selective printing of cellular components, such as cartilage rings and epithelium lining, is then performed on the outer grooves and inner surface of the bellows framework by a rotational printing process. With this strategy, 3D bioprinting of a tracheamimetic cellular construct of clinically relevant size is achieved in significantly less total printing time compared to a typical extrusion-based 3D bioprinting strategy which requires printing of an additional sacrificial material. Tracheal cartilage formation was successfully demonstrated in a nude mouse model through a subcutaneous implantation study of trachea-mimetic cellular constructs wrapped with a sinusoidal-patterned tubular mesh preventing rapid resorption of cartilage rings in vivo. This two-step 3D bioprinting for a trachea-mimetic cellular construct of clinically relevant size can provide a fundamental step towards clinical translation of 3D bioprinting based tracheal reconstruction. | - |
dc.language | English | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.relation.isPartOf | Biomaterials | - |
dc.title | 3D bioprinting of a trachea-mimetic cellular construct of a clinically relevant size | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2021.121246 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biomaterials, v.279, pp.121246 | - |
dc.identifier.wosid | 000719373100001 | - |
dc.citation.startPage | 121246 | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 279 | - |
dc.contributor.affiliatedAuthor | Cho, Dong-Woo | - |
dc.identifier.scopusid | 2-s2.0-85118826642 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TISSUE-ENGINEERED TRACHEA | - |
dc.subject.keywordPlus | SURFACE MODIFICATION | - |
dc.subject.keywordPlus | PLASMA TREATMENT | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | RECONSTRUCTION | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordPlus | POLYCAPROLACTONE | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | TURBINATE | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordAuthor | 3D bioprinting | - |
dc.subject.keywordAuthor | Trachea-mimetic cellular construct | - |
dc.subject.keywordAuthor | Clinically relevant size | - |
dc.subject.keywordAuthor | Tracheal cartilage regeneration | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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