Article
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library SCOPUS
- Title
- Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library
- Authors
- Naoki Miyamoto; Young-Hyun Go; Larissa Miasiro Ciaramicoli; Haw-Young Kwon; Heon Seok Kim; Xuezhi Bi; Young Hyun Yu; Beomsue Kim; Hyung-Ho Ha; Kang, Nam-Young; Seong-Wook Yun; Jin-Soo Kim; Hyuk-Jin Cha; CHANG, YOUNG TAE
- Date Issued
- 2021-12
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- CDy1 is a powerful tool to distingusih embryonic stem cells for reprogramming studies and regeneration medicine. However, the stem cell selectivity mechanism of CDy1 has not been fully understood. Here, we report ALDH2 and ABCB1 as the molecular targets of CDy1, elucidated by live-cell affinity-matrix and ABC transporter CRISPRa library screening. The two unique orthogonal mechanisms provide the potential of multi-demensional cellular distinction of specific cell types.
- ISSN
- 2633-0679
- Article Type
- Article
- Citation
- Rsc Chemical Biology, vol. 2, no. 6, page. 1590 - 1593, 2021-12
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Communities & Collection
Related Researcher
- 장영태CHANG, YOUNG TAE
- Dept of Chemistry