DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, SA | - |
dc.contributor.author | You, S | - |
dc.contributor.author | Yoon, HJ | - |
dc.contributor.author | Kim, DH | - |
dc.contributor.author | Kim, HS | - |
dc.contributor.author | Lee, K | - |
dc.contributor.author | Ahn, JH | - |
dc.contributor.author | Hwang, D | - |
dc.contributor.author | Lee, AS | - |
dc.contributor.author | Kim, KJ | - |
dc.contributor.author | Park, YJ | - |
dc.contributor.author | Cho, CS | - |
dc.contributor.author | Kim, WU | - |
dc.date.accessioned | 2015-06-25T02:22:57Z | - |
dc.date.available | 2015-06-25T02:22:57Z | - |
dc.date.created | 2012-08-17 | - |
dc.date.issued | 2012-04-09 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.other | 2015-OAK-0000025784 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10854 | - |
dc.description.abstract | An accumulation of misfolded proteins can trigger a cellular survival response in the endoplasmic reticulum (ER). In this study, we found that ER stress-associated gene signatures were highly expressed in rheumatoid arthritis (RA) synoviums and synovial cells. Proinflammatory cytokines, such as TNF and IL-1 beta, increased the expression of GRP78/BiP, a representative ER chaperone, in RA synoviocytes. RA synoviocytes expressed higher levels of GRP78 than osteoarthritis (OA) synoviocytes when stimulated by thapsigargin or proinflammatory cytokines. Down-regulation of Grp78 transcripts increased the apoptosis of RA synoviocytes while abolishing TNF- or TGF-beta-induced synoviocyte proliferation and cyclin D1 up-regulation. Conversely, overexpression of the Grp78 gene prevented synoviocyte apoptosis. Moreover, Grp78 small interfering RNA inhibited VEGF(165)-induced angiogenesis in vitro and also significantly impeded synoviocyte proliferation and angiogenesis in Matrigel implants engrafted into immunodeficient mice. Additionally, repeated intraarticular injections of BiP-inducible factor X, a selective GRP78 inducer, increased synoviocyte proliferation and angiogenesis in the joints of mice with experimental OA. In contrast, mice with Grp78 haploinsufficiency exhibited the suppression of experimentally induced arthritis and developed a limited degree of synovial proliferation and angiogenesis. In summary, this study shows that the ER chaperone GRP78 is crucial for synoviocyte proliferation and angiogenesis, the pathological hallmark of RA. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1084/JEM.20111783 | - |
dc.author.google | Yoo, SA | en_US |
dc.author.google | You, S | en_US |
dc.author.google | Kim, WU | en_US |
dc.author.google | Cho, CS | en_US |
dc.author.google | Park, YJ | en_US |
dc.author.google | Kim, KJ | en_US |
dc.author.google | Lee, AS | en_US |
dc.author.google | Hwang, D | en_US |
dc.author.google | Ahn, JH | en_US |
dc.author.google | Lee, K | en_US |
dc.author.google | Kim, HS | en_US |
dc.author.google | Kim, DH | en_US |
dc.author.google | Yoon, HJ | en_US |
dc.relation.volume | 209 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.startpage | 871 | en_US |
dc.relation.lastpage | 886 | en_US |
dc.contributor.id | 10180943 | en_US |
dc.relation.journal | JOURNAL OF EXPERIMENTAL MEDICINE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.209, no.4, pp.871 - 886 | - |
dc.identifier.wosid | 000302782300017 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 886 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 871 | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 209 | - |
dc.contributor.affiliatedAuthor | Hwang, D | - |
dc.identifier.scopusid | 2-s2.0-84861755093 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 71 | - |
dc.description.scptc | 73 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | SYNOVIAL FIBROBLASTS | - |
dc.subject.keywordPlus | REGULATOR GRP78/BIP | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NEURONAL DEATH | - |
dc.subject.keywordPlus | CELL-SURVIVAL | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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