DC Field | Value | Language |
---|---|---|
dc.contributor.author | Neumann, C | - |
dc.contributor.author | Heinrich, F | - |
dc.contributor.author | Neumann, K | - |
dc.contributor.author | Junghans, V | - |
dc.contributor.author | Mashreghi, MF | - |
dc.contributor.author | Ahlers, J | - |
dc.contributor.author | Janke, M | - |
dc.contributor.author | Rudolph, C | - |
dc.contributor.author | Mockel-Tenbrinck, N | - |
dc.contributor.author | Kuhl, AA | - |
dc.contributor.author | Heimesaat, MM | - |
dc.contributor.author | Esser, C | - |
dc.contributor.author | Im, SH | - |
dc.contributor.author | Radbruch, A | - |
dc.contributor.author | Rutz, S | - |
dc.contributor.author | Scheffold, A | - |
dc.date.accessioned | 2015-06-25T02:22:59Z | - |
dc.date.available | 2015-06-25T02:22:59Z | - |
dc.date.created | 2015-02-23 | - |
dc.date.issued | 2014-08-25 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.other | 2015-OAK-0000031985 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10855 | - |
dc.description.abstract | Secretion of the immunosuppressive cytokine interleukin (IL) 10 by effector T cells is an essential mechanism of self-limitation during infection. However, the transcriptional regulation of IL-10 expression in proinflammatory T helper (Th) 1 cells is insufficiently understood. We report a crucial role for the transcriptional regulator Blimp-1, induced by IL-12 in a STAT4-dependent manner, in controlling IL-10 expression in Th1 cells. Blimp-1 deficiency led to excessive inflammation during Toxoplasma gondii infection with increased mortality. IL-10 production from Th1 cells was strictly dependent on Blimp-1 but was further enhanced by the synergistic function of c-Maf, a transcriptional regulator of IL-10 induced by multiple factors, such as the Notch pathway. We found Blimp-1 expression, which was also broadly induced by IL-27 in effector T cells, to be antagonized by transforming growth factor (TGF) beta. While effectively blocking IL-10 production from Th1 cells, TGF-beta shifted IL-10 regulation from a Blimp-1-dependent to a Blimp-1-independent pathway in IL-27-induced Tr1 (T regulatory 1) cells. Our findings further illustrate how IL-10 regulation in Th cells relies on several transcriptional programs that integrate various signals from the environment to fine-tune expression of this critical immunosuppressive cytokine. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Role of Blimp-1 in programing Th effector cells into IL-10 producers | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1084/JEM.20131548 | - |
dc.author.google | Neumann, C | en_US |
dc.author.google | Heinrich, F | en_US |
dc.author.google | Scheffold, A | en_US |
dc.author.google | Rutz, S | en_US |
dc.author.google | Radbruch, A | en_US |
dc.author.google | Im, SH | en_US |
dc.author.google | Esser, C | en_US |
dc.author.google | Heimesaat, MM | en_US |
dc.author.google | Kuhl, AA | en_US |
dc.author.google | Mockel-Tenbrinck, N | en_US |
dc.author.google | Rudolph, C | en_US |
dc.author.google | Janke, M | en_US |
dc.author.google | Ahlers, J | en_US |
dc.author.google | Mashreghi, MF | en_US |
dc.author.google | Junghans, V | en_US |
dc.author.google | Neumann, K | en_US |
dc.relation.volume | 211 | en_US |
dc.relation.issue | 9 | en_US |
dc.relation.startpage | 1807 | en_US |
dc.relation.lastpage | 1819 | en_US |
dc.contributor.id | 10086785 | en_US |
dc.relation.journal | JOURNAL OF EXPERIMENTAL MEDICINE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.211, no.9, pp.1807 - 1819 | - |
dc.identifier.wosid | 000342744500011 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1819 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1807 | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 211 | - |
dc.contributor.affiliatedAuthor | Im, SH | - |
dc.identifier.scopusid | 2-s2.0-84906534462 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 53 | - |
dc.description.scptc | 48 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FACTOR C-MAF | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REPRESSOR BLIMP-1 | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | TOXOPLASMA-GONDII | - |
dc.subject.keywordPlus | CD154 EXPRESSION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | T(H)17 CELLS | - |
dc.subject.keywordPlus | IL-27 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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