DC Field | Value | Language |
---|---|---|
dc.contributor.author | Madireddi, S | - |
dc.contributor.author | Eun, SY | - |
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Nemcovicova, I | - |
dc.contributor.author | Mehta, AK | - |
dc.contributor.author | Zajonc, DM | - |
dc.contributor.author | Nishi, N | - |
dc.contributor.author | Niki, T | - |
dc.contributor.author | Hirashima, M | - |
dc.contributor.author | Croft, M | - |
dc.date.accessioned | 2015-06-25T02:23:01Z | - |
dc.date.available | 2015-06-25T02:23:01Z | - |
dc.date.created | 2014-09-02 | - |
dc.date.issued | 2014-06-30 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.other | 2015-OAK-0000030227 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10856 | - |
dc.description.abstract | Biologics to TNF family receptors are prime candidates for therapy of immune disease. Whereas recent studies have highlighted a requirement for Fc gamma receptors in enabling the activity of CD40, TRAILR, and GITR when engaged by antibodies, other TNFR molecules may be controlled by additional mechanisms. Antibodies to 4-1BB (CD137) are currently in clinical trials and can both augment immunity in cancer and promote regulatory T cells that inhibit autoimmune disease. We found that the action of agonist anti-4-1BB in suppressing autoimmune and allergic inflammation was completely dependent on Galectin-9 (Gal-9). Gal-9 directly bound to 4-1BB, in a site distinct from the binding site of antibodies and the natural ligand of 4-1BB, and Gal-9 facilitated 4-1BB aggregation, signaling, and functional activity in T cells, dendritic cells, and natural killer cells. Conservation of the Gal-9 interaction in humans has important implications for effective clinical targeting of 4-1BB and possibly other TNFR superfamily molecules. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | Rockefeller University | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1084/JEM.20132687 | - |
dc.author.google | Madireddi, S | en_US |
dc.author.google | Eun, SY | en_US |
dc.author.google | Croft, M | en_US |
dc.author.google | Hirashima, M | en_US |
dc.author.google | Niki, T | en_US |
dc.author.google | Nishi, N | en_US |
dc.author.google | Zajonc, DM | en_US |
dc.author.google | Mehta, AK | en_US |
dc.author.google | Nemcovicova, I | en_US |
dc.author.google | Lee, SW | en_US |
dc.relation.startpage | 1433 | en_US |
dc.relation.lastpage | 1448 | en_US |
dc.contributor.id | 10113012 | en_US |
dc.relation.journal | JOURNAL OF EXPERIMENTAL MEDICINE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.211, no.7, pp.1433 - 1448 | - |
dc.identifier.wosid | 000338927200014 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1448 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1433 | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 211 | - |
dc.contributor.affiliatedAuthor | Lee, SW | - |
dc.identifier.scopusid | 2-s2.0-84903771223 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 46 | - |
dc.description.scptc | 42 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | TNF-RECEPTOR FAMILY | - |
dc.subject.keywordPlus | CARBOHYDRATE-RECOGNITION | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ALLERGIC-ASTHMA | - |
dc.subject.keywordPlus | HUMAN 4-1BB | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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