DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung Wook | - |
dc.contributor.author | Hong, In Kyung | - |
dc.contributor.author | Kim, Mingee | - |
dc.contributor.author | Song, Yun Seon | - |
dc.contributor.author | Kim, Kyong-Tai | - |
dc.date.accessioned | 2022-01-18T00:20:09Z | - |
dc.date.available | 2022-01-18T00:20:09Z | - |
dc.date.created | 2021-12-27 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/109172 | - |
dc.description.abstract | Protein aggregates of cofilin and actin have been found in neurons under oxygen-glucose deprivation. However, the regulatory mechanism behind the expression of Cfl1 during oxygen-glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1 regulate the translation of Cfl1 mRNA, and formation of cofilin-actin aggregates. The interaction between hnRNP A1 and Cfl1 mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of Cfl1 mRNA under oxygen-glucose deprived conditions. These findings reveal a new translational regulatory mechanism of Cfl1 mRNA in hippocampal neurons under oxygen-glucose deprivation. | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.relation.isPartOf | Cells | - |
dc.title | hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/cells10123567 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Cells, v.10, no.12 | - |
dc.identifier.wosid | 000736086200001 | - |
dc.citation.number | 12 | - |
dc.citation.title | Cells | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Kim, Sung Wook | - |
dc.identifier.scopusid | 2-s2.0-85121302646 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | ACTIN RODS | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Cofilin–actin aggregates | - |
dc.subject.keywordAuthor | MRNA translation | - |
dc.subject.keywordAuthor | Neurodegeneration | - |
dc.subject.keywordAuthor | Oxygen–glucose deprivation | - |
dc.subject.keywordAuthor | RNA-binding proteins | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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