Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation
SCOPUS
- Title
- Long-term Non-Anesthetic Preclinical Study Available Extra-Cranial Brain Activator (ECBA) System for the Future Minimally-Invasive Human Neuro-Modulation
- Authors
- Lee, Hyungwoo; Mun, Jun Seung; San Lee, Jin; Chung, Yeongu; Jung, Woo Ram; Seong Kang, Joon; Park, Sung Min; Kang, Wonok; Kim, Se Hyeon; Won Seo, Dae; Na, Duk L.; Shon, Young-Min; Kim, Sang Joon
- Date Issued
- 2020-07
- Publisher
- IEEE
- Abstract
- Long-term preclinical study available extracranial brain activator (ECBA) system, ECBAv2, is proposed for the non-anesthetic canine models. The titanium-packaged module shows enhanced durability, even after a year of implantation in the scalp. In addition, the wearable helmet type base station provides a stable experimental environment without anesthesia. In this work, HFS stimulation is induced to six canine models for 30 minutes every day over 4 weeks (10Hz, 40Hz and no stimulation for each pair of subjects). Pre- and post-HFS stimulation PET-CT image shows remarkable increases of glucose metabolism in the temporal and parietal lobes. Moreover, both the 40-Hz and 10-Hz groups shows noticeable increase and the former group has more increments than the latter. Our results establish that HFS stimulation definitely worked as facilitating brain activity which may affect memory and sensory skills, respectively.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/109217
- DOI
- 10.1109/embc44109.2020.9176408
- ISSN
- 1557-170X
- Article Type
- Article
- Citation
- 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), page. 5184 - 5187, 2020-07
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.