Advances in Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS)-Based Techniques for Elucidating Higher-Order Protein Structures
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- Title
- Advances in Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS)-Based Techniques for Elucidating Higher-Order Protein Structures
- Authors
- SEO, JONGCHEOL
- Date Issued
- 2020-12
- Publisher
- 사단법인 한국질량분석학회
- Abstract
- Despite its great success in the field of proteomics, mass spectrometry has limited use for determining structural details of peptides, proteins, and their assemblies. Emerging ion mobility spectrometry-mass spectrometry has enabled us to explore the conformational space of protein ions in the gas phase, and further combinations with the gas-phase ion spectroscopy and the colli- sion-induced unfolding have extended its abilities to elucidating the secondary structure and local details of conformational transi- tions. This review will provide a brief introduction to the combined approaches of IMS-MS with gas-phase ion infrared spectroscopy or collision-induced unfolding and their most recent results that successfully revealed higher-order structural details.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/109530
- DOI
- 10.5478/MSL.2020.11.4.65
- ISSN
- 2233-4203
- Article Type
- Article
- Citation
- Mass Spectrometry Letters, vol. 11, no. 4, page. 65 - 70, 2020-12
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