DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Sun Mi | - |
dc.contributor.author | Lee, A-Yeon | - |
dc.contributor.author | Hwang, Sung-Min | - |
dc.contributor.author | Ha, Yu-Jin | - |
dc.contributor.author | Kim, Moo-Jin | - |
dc.contributor.author | Min, Seongki | - |
dc.contributor.author | Hwang, Won | - |
dc.contributor.author | Yoon, Gyesoon | - |
dc.contributor.author | Kwon, So Mee | - |
dc.contributor.author | Woo, Hyun Goo | - |
dc.contributor.author | Kim, Hee-Hoon | - |
dc.contributor.author | Jeong, Won-Il | - |
dc.contributor.author | Shen, Han-Ming | - |
dc.contributor.author | Im, Sin-Hyeog | - |
dc.contributor.author | Lee, Dakeun | - |
dc.contributor.author | Kim, You-Sun | - |
dc.date.accessioned | 2022-02-28T10:20:07Z | - |
dc.date.available | 2022-02-28T10:20:07Z | - |
dc.date.created | 2022-02-28 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2213-2317 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/109585 | - |
dc.description.abstract | Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage pathway and plays a crucial role in the maintenance of the NAD+ pool during inflammation. Considering that macrophages are essential for tissue homeostasis and inflammation, we sought to examine the functional impact of NAMPT in inflammatory macrophages, particularly in the context of inflammatory bowel disease (IBD). In this study, we show that mice with NAMPT deletion within the myeloid compartment (Namptf/fLysMCre+/-, Nampt mKO) have more pronounced colitis with lower survival rates, as well as numerous uncleared apoptotic corpses within the mucosal layer. Nampt-deficient macrophages exhibit reduced phagocytic activity due to insufficient NAD+ abundance, which is required to produce NADPH for the oxidative burst. Nicotinamide mononucleotide (NMN) treatment rescues NADPH levels in Nampt mKO macrophages and sustains superoxide generation via NADPH oxidase. Consequently, Nampt mKO mice fail to clear dead cells during tissue repair, leading to substantially prolonged chronic colitis. Moreover, systemic administration of NMN, to supply NAD+, effectively suppresses the disease severity of DSS-induced colitis. Collectively, our findings suggest that activation of the NAMPT-dependent NAD+ biosynthetic pathway, via NMN administration, is a potential therapeutic strategy for managing inflammatory diseases. | - |
dc.language | English | - |
dc.publisher | Elsevier BV | - |
dc.relation.isPartOf | Redox Biology | - |
dc.title | NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.redox.2022.102237 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Redox Biology, v.50 | - |
dc.identifier.wosid | 000788269000003 | - |
dc.citation.title | Redox Biology | - |
dc.citation.volume | 50 | - |
dc.contributor.affiliatedAuthor | Im, Sin-Hyeog | - |
dc.identifier.scopusid | 2-s2.0-85123090116 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLONY-ENHANCING FACTOR | - |
dc.subject.keywordPlus | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | - |
dc.subject.keywordPlus | NAD | - |
dc.subject.keywordPlus | NAMPT | - |
dc.subject.keywordPlus | MONONUCLEOTIDE | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordAuthor | NAMPT | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | Phagocytic activity | - |
dc.subject.keywordAuthor | <p>NAD(+)</p> | - |
dc.subject.keywordAuthor | Inflammatory bowel disease | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.