Multi-channel Trans-impedance Leadforming for Cardiopulmonary Monitoring: Algorithm Development and Feasibility Assessment using In Vivo Animal Data
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- Title
- Multi-channel Trans-impedance Leadforming for Cardiopulmonary Monitoring: Algorithm Development and Feasibility Assessment using In Vivo Animal Data
- Authors
- Lee, Kyounghun; Jang, Geuk Young; Kim, Yongmin; Woo, Eung Je
- Date Issued
- 2022-06
- Publisher
- Institute of Electrical and Electronics Engineers
- Abstract
- IEEEObjective: The objectives of this study were to (1) develop a multi-channel trans-impedance leadforming method for beat-to-beat stroke volume (SV) and breath-by-breath tidal volume (TV) measurements and (2) assess its feasibility on an existing in vivo animal dataset. Methods: A deterministic leadforming algorithm was developed to extract a cardiac volume signal (CVS) and a respiratory volume signal (RVS) from 208-channel trans-impedance data acquired every 20 ms by an electrical impedance tomography (EIT) device. SV<sub>EIT</sub> and TV<sub>EIT</sub> values were computed as a valley-to-peak value in the CVS and RVS, respectively. The method was applied to the existing dataset from five mechanically-ventilated pigs undergoing ten mini-fluid challenges. An invasive hemodynamic monitor was used in the arterial pressure-based cardiac output (APCO) mode to simultaneously measure SV<sub>APCO</sub> values while a mechanical ventilator provided TV<sub>Vent</sub> values. Results: The leadforming method could reliably extract the CVS and RVS from the 208-channel trans-impedance data measured with the EIT device, from which SV<sub>EIT</sub> and TV<sub>EIT</sub> were computed. The SV<sub>EIT</sub> and TV<sub>EIT</sub> values were comparable to those from the invasive hemodynamic monitor and mechanical ventilator. Using the data from 5 pigs and a simple calibration method to remove bias, the error in SV<sub>EIT<sub> and TV<sub>EIT<sub> was 9.5% and 5.4%, respectively. Conclusion: We developed a new leadforming method for the EIT device to robustly extract both SV and TV values in a deterministic fashion. Future animal and clinical studies are needed to validate this leadforming method in various subject populations. Significance: The leadforming method could be an integral component for a new cardiopulmonary monitor in the future to simultaneously measure SV and TV noninvasively, which would be beneficial to patients.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/110876
- DOI
- 10.1109/TBME.2021.3132012
- ISSN
- 0018-9294
- Article Type
- Article
- Citation
- IEEE Transactions on Biomedical Engineering, vol. 69, no. 6, page. 1964 - 1974, 2022-06
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