DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Cho, JH | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2015-06-25T02:36:56Z | - |
dc.date.available | 2015-06-25T02:36:56Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 1998-10 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.other | 2015-OAK-0000000400 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11303 | - |
dc.description.abstract | In this study, we have constructed various DNA vaccine vectors that carried hepatitis C virus (HCV) envelope genes without and with the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in several different ways. In Buffalo rats that received plasmids carrying the HCV envelope genes, which encode envelope proteins El and E2, both antibody and lymphoproliferative responses against these proteins were induced. These responses were greatly enhanced by the codelivery of the GM-CSF gene. In particular, inoculation with a bicistronic plasmid that independently expressed the GM-CSF gene and the envelope genes in the same construct generated the highest antibody titers and significantly increased lymphoproliferative responses against these proteins. Moreover, strong antibody responses to homologous and heterologous hypervariable region 1 peptides were elicited in the immunized rats. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | JOURNAL OF VIROLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage colony-stimulating factor gene | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1128/JVI.72.10.8430-8436.1998 | - |
dc.author.google | LEE, SW | en_US |
dc.author.google | CHO, JH | en_US |
dc.author.google | SUNG, YC | en_US |
dc.relation.volume | 72 | en_US |
dc.relation.issue | 10 | en_US |
dc.relation.startpage | 8430 | en_US |
dc.relation.lastpage | 8436 | en_US |
dc.contributor.id | 10053752 | en_US |
dc.relation.journal | JOURNAL OF VIROLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIROLOGY, v.72, no.10, pp.8430 - 8436 | - |
dc.identifier.wosid | 000075864100093 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 8436 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 8430 | - |
dc.citation.title | JOURNAL OF VIROLOGY | - |
dc.citation.volume | 72 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0031664801 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 69 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NON-B-HEPATITIS | - |
dc.subject.keywordPlus | HYPERVARIABLE REGION-1 | - |
dc.subject.keywordPlus | NON-A | - |
dc.subject.keywordPlus | PROTECTIVE IMMUNITY | - |
dc.subject.keywordPlus | INFECTED PATIENTS | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | GLYCOPROTEIN | - |
dc.subject.keywordPlus | IMMUNIZATION | - |
dc.subject.keywordPlus | VACCINATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
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