DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, JW | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Cho, JH | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2015-06-25T02:37:08Z | - |
dc.date.available | 2015-06-25T02:37:08Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2003-11 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.other | 2015-OAK-0000003764 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11309 | - |
dc.description.abstract | Although DNA immunization is a safe and efficient method for inducing cellular immune responses, it generates relatively weak and slow immune responses. Here, we investigated the effect of hepatitis C virus (HCV) antigen modifications on the induction of T-cell responses in DNA immunization. It is likely that the strength of T-cell responses has an inverse relationship with the length of the insert DNA. Interestingly, a mixture of several plasmids carrying each gene induced a higher level of T-cell responses than a single plasmid expressing a long polyprotein. Moreover, the presence of a transmembrane domain in HCV E2 resulted in stronger T-cell responses against E2 protein than its absence. Taken together, our results indicate that the tailored modifications of DNA-encoded antigens are capable of optimizing the induction of T-cell responses which is required for eliminating the cells chronically infected with highly variable viruses such as HCV and human immunodeficiency virus. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | JOURNAL OF VIROLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Optimal induction of T-cell responses against hepatitis C virus E2 by antigen engineering in DNA immunization | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1128/JVI.77.21.11596-11602.2003 | - |
dc.author.google | Youn, JW | en_US |
dc.author.google | Park, SH | en_US |
dc.author.google | Sung, YC | en_US |
dc.author.google | Cho, JH | en_US |
dc.relation.volume | 77 | en_US |
dc.relation.issue | 21 | en_US |
dc.relation.startpage | 11596 | en_US |
dc.relation.lastpage | 11602 | en_US |
dc.contributor.id | 10053752 | en_US |
dc.relation.journal | JOURNAL OF VIROLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIROLOGY, v.77, no.21, pp.11596 - 11602 | - |
dc.identifier.wosid | 000185995300030 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 11602 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 11596 | - |
dc.citation.title | JOURNAL OF VIROLOGY | - |
dc.citation.volume | 77 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0142028863 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 22 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HUMORAL IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | ANTIBODY-RESPONSES | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CTL | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | LYMPHOCYTE | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
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