DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Ji-Ho | - |
dc.contributor.author | Ahn, Gwang-Noh | - |
dc.contributor.author | Lee, Heekwon | - |
dc.contributor.author | Yim, Se-Jun | - |
dc.contributor.author | Lahore, Santosh | - |
dc.contributor.author | Lee, Hyune-Jea | - |
dc.contributor.author | Kim, Heejin | - |
dc.contributor.author | Kim, Ji Tae | - |
dc.contributor.author | Kim, Dong-Pyo | - |
dc.date.accessioned | 2022-06-23T04:40:25Z | - |
dc.date.available | 2022-06-23T04:40:25Z | - |
dc.date.created | 2022-03-03 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 2374-7943 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/113126 | - |
dc.description.abstract | © Continuous-flow microreactors enable ultrafast chemistry; however, their small capacity restricts industrial-level productivity of pharmaceutical compounds. In this work, scale-up subsecond synthesis of drug scaffolds was achieved via a 16 numbered-up printed metal microreactor (16N-PMR) assembly to render high productivity up to 20 g for 10 min operation. Initially, ultrafast synthetic chemistry of unstable lithiated intermediates in the halogen-lithium exchange reactions of three aryl halides and subsequent reactions with diverse electrophiles were carried out using a single microreactor (SMR). Larger production of the ultrafast synthesis was achieved by devising a monolithic module of 4 numbered-up 3D-printed metal microreactor (4N-PMR) that was integrated by laminating four SMRs and four bifurcation flow distributors in a compact manner. Eventually, the 16N-PMR system for the scalable subsecond synthesis of three drug scaffolds was assembled by stacking four monolithic modules of 4N-PMRs. | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ACS Central Science | - |
dc.title | Scalable Subsecond Synthesis of Drug Scaffolds via Aryllithium Intermediates by Numbered-up 3D-Printed Metal Microreactors | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acscentsci.1c00972 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACS Central Science, v.8, no.1, pp.43 - 50 | - |
dc.identifier.wosid | 000736554200001 | - |
dc.citation.endPage | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.title | ACS Central Science | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Kang, Ji-Ho | - |
dc.contributor.affiliatedAuthor | Ahn, Gwang-Noh | - |
dc.contributor.affiliatedAuthor | Yim, Se-Jun | - |
dc.contributor.affiliatedAuthor | Lahore, Santosh | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Pyo | - |
dc.identifier.scopusid | 2-s2.0-85122356673 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FLOW CHEMISTRY | - |
dc.subject.keywordPlus | FLASH CHEMISTRY | - |
dc.subject.keywordPlus | SERIAL MICROREACTIONS | - |
dc.subject.keywordPlus | TECHNOLOGY | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordPlus | GREEN | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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