DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, J. | - |
dc.contributor.author | Kim, K. | - |
dc.contributor.author | Park, J. | - |
dc.contributor.author | Kim, M.-J. | - |
dc.date.accessioned | 2022-06-29T10:20:40Z | - |
dc.date.available | 2022-06-29T10:20:40Z | - |
dc.date.created | 2021-11-28 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/113259 | - |
dc.description.abstract | We have developed a protocol incuding dynamic kinetic resolution as the key step for the asymmetric synthesis of biaryl diol stereoisomers. The two aryl alkanols as the starting materials were cross-coupled by palladium catalysis to give dl- and meso-diol, which were then subject to chemoenzymatic dynamic kinetic resolution (DKR) for the transformation into single stereoisomeric diol diester. Diol diester was finally deacylated to give the corresponding biaryl diol stereoisomer. The chemoenzymatic DKR was performed with a ruthenium-based racemization catalyst and a (R)-selective lipoprotein lipase. Total 17 (R,R)-diols including 7 C2-symmetric diols were synthesized with excellent enantiopurities (>99% ee). ? 2021 Korean Chemical Society, Seoul & Wiley-VCH GmbH | - |
dc.language | English | - |
dc.publisher | 대한화학회 | - |
dc.relation.isPartOf | Bulletin of the Korean Chemical Society | - |
dc.title | Asymmetric Synthesis of Biaryl Diols via Dynamic Kinetic Resolution | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bkcs.12337 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.42, no.7, pp.1028 - 1032 | - |
dc.identifier.wosid | 000659027700001 | - |
dc.citation.endPage | 1032 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1028 | - |
dc.citation.title | Bulletin of the Korean Chemical Society | - |
dc.citation.volume | 42 | - |
dc.contributor.affiliatedAuthor | Kim, K. | - |
dc.contributor.affiliatedAuthor | Park, J. | - |
dc.contributor.affiliatedAuthor | Kim, M.-J. | - |
dc.identifier.scopusid | 2-s2.0-85107536181 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | Stereochemistry | - |
dc.subject.keywordPlus | Alkanols | - |
dc.subject.keywordPlus | Asymmetric synthesis | - |
dc.subject.keywordPlus | Cross-coupled | - |
dc.subject.keywordPlus | Diesters | - |
dc.subject.keywordPlus | Dynamic kinetic resolution | - |
dc.subject.keywordPlus | Lipoprotein lipase | - |
dc.subject.keywordPlus | Palladium catalysis | - |
dc.subject.keywordPlus | Kinetics | - |
dc.subject.keywordAuthor | Asymmetric synthesis | - |
dc.subject.keywordAuthor | Biaryl diols | - |
dc.subject.keywordAuthor | Dynamic kinetic resolution | - |
dc.subject.keywordAuthor | Lipase | - |
dc.subject.keywordAuthor | Ruthenium catalyst | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Chemistry | - |
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