CYTOKININ-RESPONSIVE GROWTH REGULATOR regulates cell expansion and cytokinin-mediated cell cycle progression
SCIE
SCOPUS
- Title
- CYTOKININ-RESPONSIVE GROWTH REGULATOR regulates cell expansion and cytokinin-mediated cell cycle progression
- Authors
- Park, Joonghyuk; Lee, Seungchul; Park, Geuntae; Cho, Hyunwoo; Choi, Daeseok; Umeda, Masaaki; Choi, Yeonhee; Hwang, Daehee; Hwang, Ildoo
- Date Issued
- 2021-07
- Publisher
- OXFORD UNIV PRESS INC
- Abstract
- The cytokinin (CK) phytohormones have long been known to activate cell proliferation in plants. However, how CKs regulate cell division and cell expansion remains unclear. Here, we reveal that a basic helix-loop-helix transcription factor, CYTOKININ-RESPONSIVE GROWTH REGULATOR (CKG), mediates CK-dependent regulation of cell expansion and cell cycle progression in Arabidopsis thaliana. The overexpression of CKG increased cell size in a ploidy-independent manner and promoted entry into the S phase of the cell cycle, especially at the seedling stage. Furthermore, CKG enhanced organ growth in a pleiotropic fashion, from embryogenesis to reproductive stages, particularly of cotyledons. In contrast, ckg loss-of-function mutants exhibited smaller cotyledons. CKG mainly regulates the expression of genes involved in the regulation of the cell cycle including WEE1. We propose that CKG provides a regulatory module that connects cell cycle progression and organ growth to CK responses.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/113292
- DOI
- 10.1093/plphys/kiab180
- ISSN
- 0032-0889
- Article Type
- Article
- Citation
- PLANT PHYSIOLOGY, vol. 186, no. 3, page. 1734 - 1746, 2021-07
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