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One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction SCIE SCOPUS
- Title
- One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction
- Authors
- Hyun, Soonsil; Park, Namjoon; Nam, So Hee; Cheon, Dae Hee; Lee, Yan; Lim, Hyun-Suk; Yu, Jaehoon
- Date Issued
- 2021-03
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- In an effort designed to discover superior inhibitors of cyclophilin D (CypD), we identified and screened members of a one-bead-one-compound (OBOC) library of cyclic peptoid analogues of cyclosporin A (CsA). The results show that the one member of this cyclic peptoid family, I11, inhibits mitochondrial membrane potential changes mediated by CypD.
- ISSN
- 1359-7345
- Article Type
- Article
- Citation
- CHEMICAL COMMUNICATIONS, vol. 57, no. 19, page. 2388 - 2391, 2021-03
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Related Researcher
- 임현석LIM, HYUN SUK
- Dept of Chemistry