In Liquid Infrared Scattering Scanning Near-Field Optical Microscopy for Chemical and Biological Nanoimaging
SCIE
SCOPUS
- Title
- In Liquid Infrared Scattering Scanning Near-Field Optical Microscopy for Chemical and Biological Nanoimaging
- Authors
- O’Callahan, Brian T.; Park, Kyoung-Duck; Novikova, Irina V.; Jian, Tengyue; Chen, Chun-Long; Muller, Eric A.; El-Khoury, Patrick Z.; Raschke, Markus B.; Lea, A. Scott
- Date Issued
- 2020-06
- Publisher
- American Chemical Society
- Abstract
- Imaging biological systems with simultaneous intrinsic chemical specificity and nanometer spatial resolution in their typical native liquid environment has remained a long-standing challenge. Here, we demonstrate a general approach of chemical nanoimaging in liquid based on infrared scattering scanning near-field optical microscopy (IR s-SNOM). It is enabled by combining AFM operation in a fluid cell with evanescent IR illumination via total internal reflection, which provides spatially confined excitation for minimized IR water absorption, reduced far-field background, and enhanced directional signal emission and sensitivity. We demonstrate in-liquid IR s-SNOM vibrational nanoimaging and conformational identification of catalase nanocrystals and spatio-spectral analysis of biomimetic peptoid sheets with monolayer sensitivity and chemical specificity at the few zeptomole level. This work establishes the principles of in-liquid and in situ IR s-SNOM spectroscopic chemical nanoimaging and its general applicability to biomolecular, cellular, catalytic, electrochemical, or other interfaces and nanosystems in liquids or solutions.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/114698
- DOI
- 10.1021/acs.nanolett.0c01291
- ISSN
- 1530-6984
- Article Type
- Article
- Citation
- Nano Letters, vol. 20, no. 6, page. 4497 - 4504, 2020-06
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