Sequential Metal Catalysis towards 7‐Oxostaurosporine and Its Non‐Natural Septanose Analogue
SCIE
SCOPUS
- Title
- Sequential Metal Catalysis towards 7‐Oxostaurosporine and Its Non‐Natural Septanose Analogue
- Authors
- Seo, Kyeongdeok; Jang, Seok Hyeon; Rhee, Young Ho
- Date Issued
- 2022-01
- Publisher
- John Wiley & Sons Ltd.
- Abstract
- We report sequential metal catalysis towards indolocarbazole glycosides. The signature event is highlighted by i) Pd0-catalyzed addition of indolocarbazole to alkoxyallene combined with ring-closing-metathesis; ii) Ru-catalyzed chemoselective olefin migration; iii) PdII-catalyzed oxidative cyclization to build the bicyclic core structure of the target compounds. This approach gave access to both natural pyranose- and non-natural septanose glycosides. A short formal synthesis of 7-oxostaurosporine was achieved via this strategy.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/116463
- DOI
- 10.1002/ange.202112524
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- Angewandte Chemie - International Edition, vol. 134, no. 3, 2022-01
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- There are no files associated with this item.
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