DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, SW | - |
dc.contributor.author | Park, K | - |
dc.contributor.author | Kwak, E | - |
dc.contributor.author | Choi, E | - |
dc.contributor.author | Lee, S | - |
dc.contributor.author | Ham, J | - |
dc.contributor.author | Kang, H | - |
dc.contributor.author | Kim, JM | - |
dc.contributor.author | Hwang, SY | - |
dc.contributor.author | Kong, YY | - |
dc.contributor.author | Lee, K | - |
dc.contributor.author | Lee, JW | - |
dc.date.accessioned | 2015-06-25T02:48:42Z | - |
dc.date.available | 2015-06-25T02:48:42Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2003-05 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2015-OAK-0000003369 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11678 | - |
dc.description.abstract | Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains. Interestingly, the second LXXLL motif is highly specific to the liver X receptors (LXRs). In cotransfection, DN2, an ASC-2 fragment encompassing this motif, exerts a potent dominant-negative effect on transactivation by LXRs, which is rescued by ectopic coexpression of the full-length ASC-2 but not by other LXXLL-type coactivators, such as SRC-1 and TRAP220. In contrast, DN2/m, in which the LXXLL motif is mutated to LXXAA to abolish the interactions with LXRs, is without any effect. Accordingly, expression of DN2, but not DN2/m, in transgenic mice results in phenotypes that are highly homologous to those previously observed with LXRalpha(-/-) mice, including a rapid accumulation of large amounts of cholesterol and down-regulation of the known lipid-metabolizing target genes of LXRalpha in the liver upon being fed a high-cholesterol diet. These results identify ASC-2 as a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1128/MCB.23.10.35 | - |
dc.author.google | Kim, SW | en_US |
dc.author.google | Park, K | en_US |
dc.author.google | L | en_US |
dc.author.google | Lee, K | en_US |
dc.author.google | Kong, YY | en_US |
dc.author.google | Hwang, SY | en_US |
dc.author.google | Kim, JM | en_US |
dc.author.google | Kang, H | en_US |
dc.author.google | Ham, J | en_US |
dc.author.google | Lee, S | en_US |
dc.author.google | Choi, E | en_US |
dc.author.google | Kwak, E | en_US |
dc.relation.volume | 23 | en_US |
dc.relation.issue | 10 | en_US |
dc.relation.startpage | 3583 | en_US |
dc.relation.lastpage | 3592 | en_US |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.23, no.10, pp.3583 - 3592 | - |
dc.identifier.wosid | 000182696100020 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 3592 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 3583 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Kong, YY | - |
dc.identifier.scopusid | 2-s2.0-0038302896 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 36 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CREB-BINDING PROTEIN | - |
dc.subject.keywordPlus | NUCLEAR-RECEPTOR | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | LXR-ALPHA | - |
dc.subject.keywordPlus | DEPENDENT TRANSACTIVATION | - |
dc.subject.keywordPlus | CHOLESTEROL EFFLUX | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | OXYSTEROL RECEPTORS | - |
dc.subject.keywordPlus | RESPONSE PATHWAY | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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