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Cited 181 time in webofscience Cited 193 time in scopus
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dc.contributor.authorGoo, YH-
dc.contributor.authorSohn, YC-
dc.contributor.authorKim, DH-
dc.contributor.authorKim, SW-
dc.contributor.authorKang, MJ-
dc.contributor.authorJung, DJ-
dc.contributor.authorKwak, E-
dc.contributor.authorBarlev, NA-
dc.contributor.authorBerger, SL-
dc.contributor.authorChow, VT-
dc.contributor.authorRoeder, RG-
dc.contributor.authorAzorsa, DO-
dc.contributor.authorMeltzer, PS-
dc.contributor.authorSuh, PG-
dc.contributor.authorSong, EJ-
dc.contributor.authorLee, KJ-
dc.contributor.authorLee, YC-
dc.contributor.authorLee, JW-
dc.date.accessioned2015-06-25T02:48:46Z-
dc.date.available2015-06-25T02:48:46Z-
dc.date.created2009-02-28-
dc.date.issued2003-01-
dc.identifier.issn0270-7306-
dc.identifier.other2015-OAK-0000003069en_US
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/11680-
dc.description.abstractMany transcription coactivators interact with nuclear receptors in a ligand- and C-terminal transactivation function (AF2)-dependent manner. These include activating signal cointegrator 2 (ASC-2), a recently isolated transcriptional coactivator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors and numerous other transcription factors. In this report, we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3, alpha/beta-tubulins, and trithorax group proteins ALR-1, ALR-2, HALR, and ASH2. In particular, ALR-1/2 and HALR contain a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities. Indeed, recombinant ALR-1, HALR, and immunopurified ASCOM exhibit very weak but specific H3-lysine 4 methylation activities in vitro, and transactivation by retinoic acid receptor appears to involve ligand-dependent recruitment of ASCOM and subsequent transient H3-lysine 4 methyllation of the promoter region in vivo. Thus, ASCOM may represent a distinct coactivator complex of nuclear receptors. Further characterization of ASCOM will lead to a better understanding of how nuclear receptors and other transcription factors mediate transcriptional activation.-
dc.description.statementofresponsibilityopenen_US
dc.languageEnglish-
dc.publisherAMER SOC MICROBIOLOGY-
dc.relation.isPartOfMOLECULAR AND CELLULAR BIOLOGY-
dc.rightsBY_NC_NDen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kren_US
dc.titleActivating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins-
dc.typeArticle-
dc.contributor.college생명과학과en_US
dc.identifier.doi10.1128/MCB.23.1.140-
dc.author.googleGoo, YHen_US
dc.author.googleSohn, YCen_US
dc.author.googleLee, JWen_US
dc.author.googleLee, YCen_US
dc.author.googleLee, KJen_US
dc.author.googleSong, EJen_US
dc.author.googleSuh, PGen_US
dc.author.googleMeltzer, PSen_US
dc.author.googleAzorsa, DOen_US
dc.author.googleRoeder, RGen_US
dc.author.googleChow, VTen_US
dc.author.googleBerger, SLen_US
dc.author.googleBarlev, NAen_US
dc.author.googleKwak, Een_US
dc.author.googleJung, DJen_US
dc.author.googleKang, MJen_US
dc.author.googleKim, SWen_US
dc.author.googleKim, DHen_US
dc.relation.volume23en_US
dc.relation.issue1en_US
dc.relation.startpage140en_US
dc.relation.lastpage149en_US
dc.contributor.id10052640en_US
dc.relation.journalMOLECULAR AND CELLULAR BIOLOGYen_US
dc.relation.indexSCI급, SCOPUS 등재논문en_US
dc.relation.sciSCIen_US
dc.collections.nameJournal Papersen_US
dc.type.rimsART-
dc.identifier.bibliographicCitationMOLECULAR AND CELLULAR BIOLOGY, v.23, no.1, pp.140 - 149-
dc.identifier.wosid000179970000013-
dc.date.tcdate2019-01-01-
dc.citation.endPage149-
dc.citation.number1-
dc.citation.startPage140-
dc.citation.titleMOLECULAR AND CELLULAR BIOLOGY-
dc.citation.volume23-
dc.contributor.affiliatedAuthorSuh, PG-
dc.identifier.scopusid2-s2.0-0037216704-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc152-
dc.type.docTypeArticle-
dc.subject.keywordPlusNUCLEAR RECEPTOR COACTIVATOR-
dc.subject.keywordPlusHISTONE H3 METHYLATION-
dc.subject.keywordPlusCREB-BINDING PROTEIN-
dc.subject.keywordPlusDEPENDENT TRANSACTIVATION-
dc.subject.keywordPlusDROSOPHILA-TRITHORAX-
dc.subject.keywordPlusINTERACTION DOMAINS-
dc.subject.keywordPlusER-ALPHA-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusCLONING-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-

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