DC Field | Value | Language |
---|---|---|
dc.contributor.author | Goo, YH | - |
dc.contributor.author | Sohn, YC | - |
dc.contributor.author | Kim, DH | - |
dc.contributor.author | Kim, SW | - |
dc.contributor.author | Kang, MJ | - |
dc.contributor.author | Jung, DJ | - |
dc.contributor.author | Kwak, E | - |
dc.contributor.author | Barlev, NA | - |
dc.contributor.author | Berger, SL | - |
dc.contributor.author | Chow, VT | - |
dc.contributor.author | Roeder, RG | - |
dc.contributor.author | Azorsa, DO | - |
dc.contributor.author | Meltzer, PS | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Song, EJ | - |
dc.contributor.author | Lee, KJ | - |
dc.contributor.author | Lee, YC | - |
dc.contributor.author | Lee, JW | - |
dc.date.accessioned | 2015-06-25T02:48:46Z | - |
dc.date.available | 2015-06-25T02:48:46Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2003-01 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2015-OAK-0000003069 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11680 | - |
dc.description.abstract | Many transcription coactivators interact with nuclear receptors in a ligand- and C-terminal transactivation function (AF2)-dependent manner. These include activating signal cointegrator 2 (ASC-2), a recently isolated transcriptional coactivator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors and numerous other transcription factors. In this report, we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3, alpha/beta-tubulins, and trithorax group proteins ALR-1, ALR-2, HALR, and ASH2. In particular, ALR-1/2 and HALR contain a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities. Indeed, recombinant ALR-1, HALR, and immunopurified ASCOM exhibit very weak but specific H3-lysine 4 methylation activities in vitro, and transactivation by retinoic acid receptor appears to involve ligand-dependent recruitment of ASCOM and subsequent transient H3-lysine 4 methyllation of the promoter region in vivo. Thus, ASCOM may represent a distinct coactivator complex of nuclear receptors. Further characterization of ASCOM will lead to a better understanding of how nuclear receptors and other transcription factors mediate transcriptional activation. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1128/MCB.23.1.140 | - |
dc.author.google | Goo, YH | en_US |
dc.author.google | Sohn, YC | en_US |
dc.author.google | Lee, JW | en_US |
dc.author.google | Lee, YC | en_US |
dc.author.google | Lee, KJ | en_US |
dc.author.google | Song, EJ | en_US |
dc.author.google | Suh, PG | en_US |
dc.author.google | Meltzer, PS | en_US |
dc.author.google | Azorsa, DO | en_US |
dc.author.google | Roeder, RG | en_US |
dc.author.google | Chow, VT | en_US |
dc.author.google | Berger, SL | en_US |
dc.author.google | Barlev, NA | en_US |
dc.author.google | Kwak, E | en_US |
dc.author.google | Jung, DJ | en_US |
dc.author.google | Kang, MJ | en_US |
dc.author.google | Kim, SW | en_US |
dc.author.google | Kim, DH | en_US |
dc.relation.volume | 23 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.startpage | 140 | en_US |
dc.relation.lastpage | 149 | en_US |
dc.contributor.id | 10052640 | en_US |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.23, no.1, pp.140 - 149 | - |
dc.identifier.wosid | 000179970000013 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 149 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 140 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-0037216704 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 152 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NUCLEAR RECEPTOR COACTIVATOR | - |
dc.subject.keywordPlus | HISTONE H3 METHYLATION | - |
dc.subject.keywordPlus | CREB-BINDING PROTEIN | - |
dc.subject.keywordPlus | DEPENDENT TRANSACTIVATION | - |
dc.subject.keywordPlus | DROSOPHILA-TRITHORAX | - |
dc.subject.keywordPlus | INTERACTION DOMAINS | - |
dc.subject.keywordPlus | ER-ALPHA | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CLONING | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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