DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, TH | - |
dc.contributor.author | Park, DY | - |
dc.contributor.author | Choi, YH | - |
dc.contributor.author | Kim, KJ | - |
dc.contributor.author | Yoon, HS | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2015-06-25T02:49:04Z | - |
dc.date.available | 2015-06-25T02:49:04Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2015-OAK-0000007352 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11689 | - |
dc.description.abstract | Mitotic chromatin condensation is essential for cell division in eukaryotes. Posttranslational modification of the N-terminal tail of histone proteins, particularly by phosphorylation by mitotic histone kinases, may facilitate this process. In mammals, aurora B is believed to be the mitotic histone H3 Ser10 kinase; however, it is not sufficient to phosphorylate H3 Ser10 with aurora B alone. We show that histone H3 is phosphorylated by vaccinia-related kinase 1 (VRK1). Direct phosphorylation of Thr3 and Ser10 in H3 by VRK1 both in vitro and in vivo was observed. Loss of VRK1 activity was associated with a marked decrease in H3 phosphorylation during mitosis. Phosphorylation of Ser10 by VRK1 is similar to that by aurora B. Moreover, expression and chromatin localization of VRK1 depended on the cell cycle phase. Overexpression of VRK1 resulted in a dramatic condensation of nuclei. Our findings collectively support a role of VRK1 as a novel mitotic histone H3 kinase in mammals. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1128/MCB.00018-07 | - |
dc.author.google | Kang, TH | en_US |
dc.author.google | Park, DY | en_US |
dc.author.google | Kim, KT | en_US |
dc.author.google | Yoon, HS | en_US |
dc.author.google | Kim, KJ | en_US |
dc.author.google | Choi, YH | en_US |
dc.relation.volume | 27 | en_US |
dc.relation.issue | 24 | en_US |
dc.relation.startpage | 8533 | en_US |
dc.relation.lastpage | 8546 | en_US |
dc.contributor.id | 10104775 | en_US |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.27, no.24, pp.8533 - 8546 | - |
dc.identifier.wosid | 000251527300011 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 8546 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 8533 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 27 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-37549026472 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 77 | - |
dc.description.scptc | 76 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | AURORA-B | - |
dc.subject.keywordPlus | CHROMOSOME CONDENSATION | - |
dc.subject.keywordPlus | H3 PHOSPHORYLATION | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | NIMA-FAMILY | - |
dc.subject.keywordPlus | VRK1 | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | SPINDLE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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