DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, B | - |
dc.contributor.author | Kim, SG | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Choi, KY | - |
dc.contributor.author | Lee, S | - |
dc.contributor.author | Lee, SK | - |
dc.contributor.author | Lee, JW | - |
dc.date.accessioned | 2015-06-25T02:49:30Z | - |
dc.date.available | 2015-06-25T02:49:30Z | - |
dc.date.created | 2013-07-02 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2015-OAK-0000027728 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11702 | - |
dc.description.abstract | The molecular basis underlying the physiologically well-defined orexigenic function of glucocorticoid (Gc) is unclear. Brain-specific homeobox factor (Bsx) is a positive regulator of the orexigenic neuropeptide, agouti-related peptide (AgRP), in AgRP neurons of the hypothalamic arcuate nucleus. Here, we show that in response to fasting-elevated Gc levels, Gc receptor (GR) and Bsx synergize to direct activation of AgRP transcription. This synergy is dictated by unique sequence features in a novel Gc response element in AgRP (AgRP-GRE). In contrast to AgRP-GRE, Bsx suppresses transactivation directed by many conventional GREs, functioning as a gene context-dependent modulator of GR actions or a target selector for GR. Consistent with this finding, AgRP-GRE drives fasting-dependent activation of a target gene specifically in GR(+) Bsx(+) AgRP neurons. These results define AgRP as a common orexigenic target gene of GR and Bsx and provide an opportunity to identify their additional common targets, facilitating our understanding of the molecular basis underlying the orexigenic activity of Gc and Bsx. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | Molecular and cellular biology | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Brain-Specific Homeobox Factor as a Target Selector for Glucocorticoid Receptor in Energy Balance. | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1128/MCB.00094-13 | - |
dc.author.google | Lee, B | en_US |
dc.author.google | Kim, SG | en_US |
dc.author.google | Lee, JW | en_US |
dc.author.google | Lee, SK | en_US |
dc.author.google | Lee, S | en_US |
dc.author.google | Choi, KY | en_US |
dc.author.google | Kim, J | en_US |
dc.relation.volume | 14 | en_US |
dc.relation.issue | 33 | en_US |
dc.relation.startpage | 2650 | en_US |
dc.relation.lastpage | 2658 | en_US |
dc.contributor.id | 10052985 | en_US |
dc.relation.journal | Molecular and cellular biology | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Molecular and cellular biology, v.14, no.33, pp.2650 - 2658 | - |
dc.identifier.wosid | 000320714400001 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2658 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 2650 | - |
dc.citation.title | Molecular and cellular biology | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Choi, KY | - |
dc.identifier.scopusid | 2-s2.0-84880660350 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 13 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ARCUATE NUCLEUS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NEUROPEPTIDE-Y | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | BSX | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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