DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, A | - |
dc.contributor.author | Lee, MN | - |
dc.contributor.author | Yang, YR | - |
dc.contributor.author | Jeong, H | - |
dc.contributor.author | Ghim, J | - |
dc.contributor.author | Noh, J | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Ryu, D | - |
dc.contributor.author | Park, S | - |
dc.contributor.author | Song, P | - |
dc.contributor.author | Koo, SH | - |
dc.contributor.author | Leslie, NR | - |
dc.contributor.author | Berggren, PO | - |
dc.contributor.author | Choi, JH | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2015-06-25T02:49:32Z | - |
dc.date.available | 2015-06-25T02:49:32Z | - |
dc.date.created | 2013-06-28 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2015-OAK-0000027698 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11703 | - |
dc.description.abstract | Muscle atrophy occurs under various catabolic conditions, including insulin deficiency, insulin resistance, or increased levels of glucocorticoids. This results from reduced levels of insulin receptor substrate 1 (IRS-1), leading to decreased phosphatidylinositol 3-kinase activity and thereby activation of FoxO transcription factors. However, the precise mechanism of reduced IRS-1 under a catabolic condition is unknown. Here, we report that C1-Ten is a novel protein tyrosine phosphatase (PTPase) of IRS-1 that acts as a mediator to reduce IRS-1 under a catabolic condition, resulting in muscle atrophy. C1-Ten preferentially dephosphorylated Y612 of IRS-1, which accelerated IRS-1 degradation. These findings suggest a novel type of IRS-1 degradation mechanism which is dependent on C1-Ten and extends our understanding of the molecular mechanism of muscle atrophy under catabolic conditions. C1-Ten expression is increased by catabolic glucocorticoid and decreased by anabolic insulin. Reflecting these hormonal regulations, the muscle C1-Ten is upregulated in atrophy but downregulated in hypertrophy. This reveals a previously unidentified role of C1-Ten as a relevant PTPase contributing to skeletal muscle atrophy. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle Atrophy | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1128/MCB.01447-12 | - |
dc.author.google | Koh, A | en_US |
dc.author.google | Lee, MN | en_US |
dc.author.google | Ryu, SH | en_US |
dc.author.google | Suh, PG | en_US |
dc.author.google | Choi, JH | en_US |
dc.author.google | Berggren, PO | en_US |
dc.author.google | Leslie, NR | en_US |
dc.author.google | Koo, SH | en_US |
dc.author.google | Song, P | en_US |
dc.author.google | Park, S | en_US |
dc.author.google | Ryu, D | en_US |
dc.author.google | Kim, J | en_US |
dc.author.google | Noh, J | en_US |
dc.author.google | Ghim, J | en_US |
dc.author.google | Jeong, H | en_US |
dc.author.google | Yang, YR | en_US |
dc.relation.volume | 33 | en_US |
dc.relation.issue | 8 | en_US |
dc.relation.startpage | 1608 | en_US |
dc.relation.lastpage | 1620 | en_US |
dc.contributor.id | 10069853 | en_US |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.33, no.8, pp.1608 - 1620 | - |
dc.identifier.wosid | 000317272500011 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1620 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1608 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 33 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-84876333589 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 17 | - |
dc.description.scptc | 15 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY | - |
dc.subject.keywordPlus | FOXO TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | HUMAN SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | GROWTH-FACTOR-II | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | UBIQUITIN LIGASES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CELL-SURVIVAL | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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