Syntheses and structural studies of calix[4]arene-nucleoside and calix[4]arene-oligonucleotide hybrids
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SCOPUS
- Title
- Syntheses and structural studies of calix[4]arene-nucleoside and calix[4]arene-oligonucleotide hybrids
- Authors
- Kim, SJ; Kim, BH
- Date Issued
- 2003-06-01
- Publisher
- OXFORD UNIV PRESS
- Abstract
- We have synthesized three types of calix[4]arene- nucleoside hybrid efficiently by amide bond formation between the amine functional groups of 1,3-diaminocalix[4]arene and the carboxyl groups of thymidine nucleoside derivatives. X-ray crystallography of a homocoupled calix[4]arene-nucleoside hybrid revealed an interesting hydrogen bonding pattern between thymine bases and the amide linkages. We designed the calix[4]arene-oligonucleotide hybrids (5'-AAAAGATATCAAXTTGATATCTTTT-3', 5'-T-12-X-T-12-3', and 5'-A(12)-X-T-12-3') to be V-shaped oligodeoxyribonucleotides and synthesized them by using a calix[4]arene-nucleoside hybrid (X) as a key building block. Thermal denaturation experiments, monitored by UV spectroscopy at 260 and 284 nm, and circular dichroism spectra of the calix[4]arene-oligonucleotide hybrids suggest that the modified oligonucleotides indeed adopt V-shaped conformations, making them suitable for use as building blocks in the construction of programmed oligonucleotide nanostructures.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/11832
- DOI
- 10.1093/NAR/GKG391
- ISSN
- 0305-1048
- Article Type
- Article
- Citation
- NUCLEIC ACIDS RESEARCH, vol. 31, no. 11, page. 2725 - 2734, 2003-06-01
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