Studies on the roles of Gcap14, a microtubule plus-end-tracking protein, on microtubule-actin crosstalk during neurodevelopment
- Title
- Studies on the roles of Gcap14, a microtubule plus-end-tracking protein, on microtubule-actin crosstalk during neurodevelopment
- Authors
- 문동진
- Date Issued
- 2023
- Publisher
- 포항공과대학교
- Abstract
- Regulation of microtubule dynamics is required to properly control various steps of
neurodevelopment. In this study, we identified granule cell antiserum-positive 14 (Gcap14) as
a microtubule plus-end-tracking protein and as a regulator of microtubule dynamics during
neurodevelopment. Gcap14 knockout mice exhibited impaired cortical lamination. Gcap14
deficiency resulted in defective neuronal migration. Moreover, nuclear distribution element
nudE-like 1 (Ndel1), an interacting partner of Gcap14, effectively corrected the downregulation
of microtubule dynamics and the defects in neuronal migration caused by Gcap14 deficiency.
Finally, we found that the Gcap14– Ndel1 complex participates in the functional link between
microtubule and actin filament, thereby regulating their crosstalks in the growth cones of
cortical neurons. Taken together, we propose that the Gcap14–Ndel1 complex is fundamental
for cytoskeletal remodeling during neurodevelopmental processes such as neuronal process
elongation and neuronal migration.
- URI
- http://postech.dcollection.net/common/orgView/200000691016
https://oasis.postech.ac.kr/handle/2014.oak/118432
- Article Type
- Thesis
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