DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, YH | - |
dc.contributor.author | Lim, JK | - |
dc.contributor.author | Jeong, MW | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2015-06-25T02:54:08Z | - |
dc.date.available | 2015-06-25T02:54:08Z | - |
dc.date.created | 2013-02-05 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.other | 2015-OAK-0000026318 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11846 | - |
dc.description.abstract | The telomere integrity is maintained via replication machinery, telomere associated proteins and telomerase. Many telomere associated proteins are regulated in a cell cycle-dependent manner. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), a single-stranded oligonucleotide binding protein, is thought to play a pivotal role in telomere maintenance. Here, we identified hnRNP A1 as a novel substrate for vaccinia-related kinase 1 (VRK1), a cell cycle regulating kinase. Phosphorylation by VRK1 potentiates the binding of hnRNP A1 to telomeric ssDNA and telomerase RNA in vitro and enhances its function for telomerase reaction. VRK1 deficiency induces a shortening of telomeres with an abnormal telomere arrangement and activation of DNA-damage signaling in mouse male germ cells. Together, our data suggest that VRK1 is required for telomere maintenance via phosphorylation of hnRNP A1, which regulates proteins associated with the telomere and telomerase RNA. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1093/NAR/GKS634 | - |
dc.author.google | Choi, YH | en_US |
dc.author.google | Lim, JK | en_US |
dc.author.google | Kim, KT | en_US |
dc.author.google | Jeong, MW | en_US |
dc.relation.volume | 40 | en_US |
dc.relation.issue | 17 | en_US |
dc.relation.startpage | 8499 | en_US |
dc.relation.lastpage | 8518 | en_US |
dc.contributor.id | 10104775 | en_US |
dc.relation.journal | NUCLEIC ACIDS RESEARCH | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.40, no.17, pp.8499 - 8518 | - |
dc.identifier.wosid | 000309464300037 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 8518 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 8499 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-84866904458 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 12 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NUCLEAR RIBONUCLEOPROTEIN A1 | - |
dc.subject.keywordPlus | STRAND ANNEALING ACTIVITY | - |
dc.subject.keywordPlus | CELL-CYCLE PROGRESSION | - |
dc.subject.keywordPlus | G-RICH STRAND | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | MAMMALIAN TELOMERES | - |
dc.subject.keywordPlus | OVERHANG GENERATION | - |
dc.subject.keywordPlus | DAMAGE CHECKPOINT | - |
dc.subject.keywordPlus | HUMAN-CHROMOSOMES | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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