DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khairallah, Camille | - |
dc.contributor.author | Bettke, Julie A. | - |
dc.contributor.author | Gorbatsevych, Oleksandr | - |
dc.contributor.author | Qiu, Zhijuan | - |
dc.contributor.author | Zhang, Yue | - |
dc.contributor.author | Cho, Kyungjin | - |
dc.contributor.author | Kim, Kwang Soon | - |
dc.contributor.author | Chu, Timothy H. | - |
dc.contributor.author | Imperato, Jessica N. | - |
dc.contributor.author | Hatano, Shinya | - |
dc.contributor.author | Romanov, Galina | - |
dc.contributor.author | Yoshikai, Yasunobo | - |
dc.contributor.author | Puddington, Lynn | - |
dc.contributor.author | Surh, Charles D. | - |
dc.contributor.author | Bliska, James B. | - |
dc.contributor.author | van der Velden, Adrianus W.M. | - |
dc.contributor.author | Sheridan, Brian S. | - |
dc.date.accessioned | 2023-10-05T01:20:28Z | - |
dc.date.available | 2023-10-05T01:20:28Z | - |
dc.date.created | 2023-10-05 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1933-0219 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/118936 | - |
dc.description.abstract | Although murine γδ T cells are largely considered innate immune cells, they have recently been reported to form long-lived memory populations. Much remains unknown about the biology and specificity of memory γδ T cells. Here, we interrogated intestinal memory Vγ4 Vδ1 T cells generated after foodborne Listeria monocytogenes (Lm) infection to uncover an unanticipated complexity in the specificity of these cells. Deep TCR sequencing revealed that a subset of non-canonical Vδ1 clones are selected by Lm infection, consistent with antigen-specific clonal expansion. Ex vivo stimulations and in vivo heterologous challenge infections with diverse pathogenic bacteria revealed that Lm-elicited memory Vγ4 Vδ1 T cells are broadly reactive. The Vγ4 Vδ1 T cell recall response to Lm, Salmonella enterica serovar Typhimurium (STm) and Citrobacter rodentium was largely mediated by the γδTCR as internalizing the γδTCR prevented T cell expansion. Both broadly-reactive canonical and pathogen-selected non-canonical Vδ1 clones contributed to memory responses to Lm and STm. Interestingly, some non-canonical γδ T cell clones selected by Lm infection also responded after STm infection, suggesting some level of cross-reactivity. These findings underscore the promiscuous nature of memory γδ T cells and suggest that pathogen-elicited memory γδ T cells are potential targets for broad-spectrum anti-infective vaccines. © 2021, The Author(s), under exclusive licence to Society for Mucosal Immunology. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Mucosal Immunology | - |
dc.title | A blend of broadly-reactive and pathogen-selected Vγ4 Vδ1 T cell receptors confer broad bacterial reactivity of resident memory γδ T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41385-021-00447-x | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Mucosal Immunology, v.15, no.1, pp.176 - 187 | - |
dc.identifier.wosid | 000691757000001 | - |
dc.citation.endPage | 187 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 176 | - |
dc.citation.title | Mucosal Immunology | - |
dc.citation.volume | 15 | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Soon | - |
dc.identifier.scopusid | 2-s2.0-85113998035 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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