Levan Based Biodegradable Hydrogels for Drug Delivery
- Title
- Levan Based Biodegradable Hydrogels for Drug Delivery
- Authors
- OSMAN, ASILA AHMED MOHMMED; Mehmet S eroglu; HWANG, DONG SOO; Ebru toksoy oner
- Date Issued
- 2022-04-15
- Publisher
- The korean society for biotechnology and bioengineering
- Abstract
- Levan based cross-linker was successfully synthesized and used to prepare a series of more biocompatible and
temperature responsive levan/N-isopropyl acrylamide (levan/pNIPA) hydrogels by redox polymer-ization at
room temperature. Volume phase transition temperature (VPTT) of the hydrogels were precisely determined by
derivative differential scanning calorimetry (DDSC). Incorporation of levan into the pNIPA hydrogel increased
the VPTT from 32.8◦C to 35.09◦C, approaching to body temperature. Swelling behavior and 5-aminosalicylic acid
(5-ASA) release of the hydrogels were found to vary significantly with temperature and composition. Moreover,
a remarkable increase in thermal stability of levan within hydrogel with increase of pNIPA content was recorded.
The biocompatibility of the hydrogels were tested against mouse fibroblast L929 cell line in phosphate buffer
saline (PBS, pH 7.4). The hydrogels showed increasing biocompatibility with increasing levan ratio, indicating
levan enhanced the hydrogel surface during swelling
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/119156
- Article Type
- Conference
- Citation
- 2022 KSBB Spring Meeting and International Symposium, 2022-04-15
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