Development of Iodinated Indocyanine Green Analogs as a Strategy for Targeted Therapy of Liver Cancer
SCIE
SCOPUS
- Title
- Development of Iodinated Indocyanine Green Analogs as a Strategy for Targeted Therapy of Liver Cancer
- Authors
- Marker, Sierra C.; Espinoza, Andres F.; King, A. Paden; Woodfield, Sarah E.; Patel, Roma H.; Baidoo, Kwamena; Nix, Meredith N.; Ciaramicoli, Larissa Miasiro; Chang, Young-Tae; Escorcia, Freddy E.; Vasudevan, Sanjeev A.; Schnermann, Martin J.
- Date Issued
- 2023-08
- Publisher
- American Chemical Society
- Abstract
- Liver cancer is one of the leading causes of cancer-related deaths, with a significant increase in incidence worldwide. Novel therapies are needed to address this unmet clinical need. Indocyanine green (ICG) is a broadly used fluorescence-guided surgery (FGS) agent for liver tumor resection and has significant potential for conversion to a targeted therapy. Here, we report the design, synthesis, and investigation of a series of iodinated ICG analogs (I-ICG), which can be used to develop ICG-based targeted radiopharmaceutical therapy. We applied a CRISPR-based screen to identify the solute carrier transporter, OATP1B3, as a likely mechanism for ICG uptake. Our lead I-ICG compound specifically localizes to tumors in mice bearing liver cancer xenografts. This study introduces the chemistry needed to incorporate iodine onto the ICG scaffold and defines the impact of these modifications on key properties, including targeting liver cancer in vitro and in vivo.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/120414
- DOI
- 10.1021/acsmedchemlett.3c00213
- ISSN
- 1948-5875
- Article Type
- Article
- Citation
- ACS Medicinal Chemistry Letters, vol. 14, no. 9, page. 1208 - 1215, 2023-08
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- There are no files associated with this item.
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