DC Field | Value | Language |
---|---|---|
dc.contributor.author | BAE, MIHYEON | - |
dc.contributor.author | Huyen Ngo | - |
dc.contributor.author | You Jung Kang | - |
dc.contributor.author | Su-Jin Lee | - |
dc.contributor.author | PARK, WONBIN | - |
dc.contributor.author | JO, YEONGGWON | - |
dc.contributor.author | CHOI, YOO MI | - |
dc.contributor.author | KIM, JOENGJU | - |
dc.contributor.author | Hee-Gyeong Yi | - |
dc.contributor.author | Hyung-Seok Kim | - |
dc.contributor.author | JANG, JIN AH | - |
dc.contributor.author | CHO, DONGWOO | - |
dc.contributor.author | Hansang Cho | - |
dc.date.accessioned | 2024-03-04T06:00:54Z | - |
dc.date.available | 2024-03-04T06:00:54Z | - |
dc.date.created | 2024-02-18 | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/120687 | - |
dc.description.abstract | Non-neural extracellular matrix (ECM) has limited application in humanized physiological neural modeling due to insufficient brain-specificity and safety concerns. Although brain-derived ECM contains enriched neural components, certain essential components are partially lost during the decellularization process, necessitating augmentation. Here, it is demonstrated that the laminin-augmented porcine brain-decellularized ECM (P-BdECM) is xenogeneic factor-depleted as well as favorable for the regulation of human neurons, astrocytes, and microglia. P-BdECM composition is comparable to human BdECM regarding brain-specificity through the matrisome and gene ontology-biological process analysis. As augmenting strategy, laminin 111 supplement promotes neural function by synergic effect with laminin 521 in P-BdECM. Annexin A1(ANXA1) and Peroxiredoxin(PRDX) in P-BdECM stabilized microglial and astrocytic behavior under normal while promoting active neuroinflammation in response to neuropathological factors. Further, supplementation of the brain-specific molecule to non-neural matrix also ameliorated glial cell inflammation as in P-BdECM. In conclusion, P-BdECM-augmentation strategy can be used to recapitulate humanized pathophysiological cerebral environments for neurological study. Porcine-derived brain decellularized extracellular matrix (P-BdECM) augmented with LN111 is developed to construct physiological human brain model. The similarity of P-BdECM is specifically validated to human BdECM and brain-specific proteins in ameliorating neural differentiation and neuroinflammation. The augmented P-BdECM is favorable to recapitulate the neural microenvironment for the study of cellular behavior and the role of ECM in neural processes.image | - |
dc.language | English | - |
dc.publisher | Wiley - V C H Verlag GmbbH & Co. | - |
dc.relation.isPartOf | Small | - |
dc.title | Laminin-Augmented Decellularized Extracellular Matrix Ameliorating Neural Differentiation and Neuroinflammation in Human Mini-Brains | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/smll.202308815 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Small, v.20, no.23 | - |
dc.identifier.wosid | 001133243000001 | - |
dc.citation.number | 23 | - |
dc.citation.title | Small | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | BAE, MIHYEON | - |
dc.contributor.affiliatedAuthor | PARK, WONBIN | - |
dc.contributor.affiliatedAuthor | JO, YEONGGWON | - |
dc.contributor.affiliatedAuthor | CHOI, YOO MI | - |
dc.contributor.affiliatedAuthor | KIM, JOENGJU | - |
dc.contributor.affiliatedAuthor | JANG, JIN AH | - |
dc.contributor.affiliatedAuthor | CHO, DONGWOO | - |
dc.identifier.scopusid | 2-s2.0-85180846708 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ANNEXIN A1 | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | MAPK | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ASTROCYTES | - |
dc.subject.keywordPlus | PEROXIREDOXINS | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | ENVIRONMENT | - |
dc.subject.keywordAuthor | cerebral decellularized extracellular matrix | - |
dc.subject.keywordAuthor | laminin | - |
dc.subject.keywordAuthor | neural differentiation | - |
dc.subject.keywordAuthor | neuroinflammation | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.