DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HyeMi | - |
dc.contributor.author | Baek, Yujin | - |
dc.contributor.author | Choi, Doowon | - |
dc.contributor.author | Lee, Woo Jin | - |
dc.contributor.author | Kim, Sungjee | - |
dc.contributor.author | Doh, Junsang | - |
dc.contributor.author | Ha, Taeyong | - |
dc.contributor.author | Cho, Yongbum | - |
dc.contributor.author | Park, Jeehun | - |
dc.date.accessioned | 2024-03-04T09:40:11Z | - |
dc.date.available | 2024-03-04T09:40:11Z | - |
dc.date.created | 2024-03-01 | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/120797 | - |
dc.description.abstract | Cancer immunotherapy is a promising therapy to treat cancer patients with minimal toxicity, but only a small fraction of patients responded to it as a monotherapy. In this study, a strategy to boost therapeutic efficacy by combining an immunotherapy based on ex vivo expanded tumor-reactive T cells is devised, or adoptive cell therapy (ACT), with photothermal therapy (PTT). Smart gold nanoparticles (sAuNPs), which aggregates to form gold nanoclusters in the cells, are loaded into T cells, and their photothermal effects within T cells are confirmed. When transferred into tumor-bearing mice, large number of sAuNP-carrying T cells successfully infiltrate into tumor tissues and exert anti-tumor activity to suspend tumor growth, but over time tumor cells evade and regrow. Of note, & AP;20% of injected doses of sAuNPs are deposited in tumor tissues, suggesting T cells are an efficient nanoparticle tumor delivery vehicle. When T cells no longer control tumor growth, PTT is performed to further eliminate tumors. In this manner, ACT and PTT are temporally coupled, and the combined immuno-photothermal treatment demonstrated significantly greater therapeutic efficacy than the monotherapy. | - |
dc.language | English | - |
dc.publisher | Wiley - V C H Verlag GmbbH & Co. | - |
dc.relation.isPartOf | Small | - |
dc.title | Gold Nanoparticle‐Carrying T Cells for the Combined Immuno‐Photothermal Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/smll.202301377 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Small, v.19, no.47 | - |
dc.identifier.wosid | 001035419500001 | - |
dc.citation.number | 47 | - |
dc.citation.title | Small | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Choi, Doowon | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Sungjee | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.contributor.affiliatedAuthor | Ha, Taeyong | - |
dc.contributor.affiliatedAuthor | Cho, Yongbum | - |
dc.identifier.scopusid | 2-s2.0-85165603922 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | adoptive cell therapy | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordAuthor | T cells | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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