DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim Chi Kyung | - |
dc.contributor.author | Yang Xiu-Li | - |
dc.contributor.author | Kim Young-Ju | - |
dc.contributor.author | Choi In-Young | - |
dc.contributor.author | Jeong Han-Gil | - |
dc.contributor.author | Park Hong-Kyun | - |
dc.contributor.author | Kim Dohoung | - |
dc.contributor.author | Kim Tae Jung | - |
dc.contributor.author | Jang Hyunduk | - |
dc.contributor.author | Ko Sang-Bae | - |
dc.contributor.author | Yoon Byung-Woo | - |
dc.date.accessioned | 2024-03-05T02:21:30Z | - |
dc.date.available | 2024-03-05T02:21:30Z | - |
dc.date.created | 2024-03-04 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/120839 | - |
dc.description.abstract | Fimasartan is a newly developed angiotensin receptor blocker, which may have protective effects during myocardial infarction or atherosclerosis. In this context, we investigated the effects of long-term treatment with low-dose fimasartan on focal ischemia in rat brain. We induced focal ischemia in brain by transient intraluminal occlusion of middle cerebral artery (MCA) and administered low-dose (0.5 mg/kg) or regular doses (1 or 3 mg/kg) of fimasartan via intravenous routes. After the administration of low-dose (0.5 mg/kg) fimasartan, blood pressure did not decrease compared to the phosphate-buffered saline-(PBS-) control with MCA occlusion (MCAO) group. The infarct volume and ischemic cell death were reduced in the low-dose fimasartan-treated group (46 +/- 41mm(3) for 0.5 mg/kg and 153 +/- 47mm(3) for PBS-control with MCAO; P < 0.01) but not in the regular-dose groups. Low-dose fimasartan treatment improved functional recovery after ischemia and significantly decreased mortality. In our study, fimasartan reduced the degradation of I kappa B and the formation of an inflammatory end-product, COX-2. As a result, the recruitment of inflammatory cells in the peri-infarct area decreased in fimasartan-treated group. We have demonstrated that long-term, lowdose fimasartan treatment improved outcomes after focal ischemia in the brain via a reduction of inflammation. | - |
dc.language | English | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.relation.isPartOf | BioMed Research International | - |
dc.title | Effect of Long-Term Treatment with Fimasartan on Transient Focal Ischemia in Rat Brain | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2015/295925 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BioMed Research International, v.2015 | - |
dc.identifier.wosid | 000362000800001 | - |
dc.citation.title | BioMed Research International | - |
dc.citation.volume | 2015 | - |
dc.contributor.affiliatedAuthor | Kim Dohoung | - |
dc.identifier.scopusid | 2-s2.0-84942803517 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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