DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, Siqi | - |
dc.contributor.author | Hur, Yun Ha | - |
dc.contributor.author | Cai, Xin | - |
dc.contributor.author | Cong, Qian | - |
dc.contributor.author | Yang, Yihao | - |
dc.contributor.author | Xu, Chiwei | - |
dc.contributor.author | Bilate, Angelina M. | - |
dc.contributor.author | Gonzales, Kevin Andrew Uy | - |
dc.contributor.author | Parigi, S. Martina | - |
dc.contributor.author | Cowley, Christopher J. | - |
dc.contributor.author | Hurwitz, Brian | - |
dc.contributor.author | Luo, Ji-Dung | - |
dc.contributor.author | Tseng, Tiffany | - |
dc.contributor.author | Gur-Cohen, Shiri | - |
dc.contributor.author | Sribour, Megan | - |
dc.contributor.author | Omelchenko, Tatiana | - |
dc.contributor.author | Levorse, John | - |
dc.contributor.author | Pasolli, Hilda Amalia | - |
dc.contributor.author | Thompson, Craig B. | - |
dc.contributor.author | Mucida, Daniel | - |
dc.contributor.author | Fuchs, Elaine | - |
dc.date.accessioned | 2024-03-05T04:40:07Z | - |
dc.date.available | 2024-03-05T04:40:07Z | - |
dc.date.created | 2024-03-04 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/120852 | - |
dc.description.abstract | Pathogen infection and tissue injury are universal insults that disrupt homeostasis. Innate immunity senses microbial infections and induces cytokines/chemokines to activate resistance mechanisms. Here, we show that, in contrast to most pathogen-induced cytokines, interleukin-24 (IL-24) is predominately induced by barrier epithelial progenitors after tissue injury and is independent of microbiome or adaptive immunity. Moreover, Il24 ablation in mice impedes not only epidermal proliferation and re-epithelialization but also capillary and fibroblast regeneration within the dermal wound bed. Conversely, ectopic IL-24 induction in the homeostatic epidermis triggers global epithelial-mesenchymal tissue repair responses. Mechanistically, Il24 expression depends upon both epithelial IL24-receptor/STAT3 signaling and hypoxia-stabilized HIF1α, which converge following injury to trigger autocrine and paracrine signaling involving IL-24-mediated receptor signaling and metabolic regulation. Thus, parallel to innate immune sensing of pathogens to resolve infections, epithelial stem cells sense injury signals to orchestrate IL-24-mediated tissue repair. © 2023 The Authors | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | Cell | - |
dc.title | A tissue injury sensing and repair pathway distinct from host pathogen defense | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cell.2023.03.031 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Cell, v.186, no.10, pp.2127 - 2143.e22 | - |
dc.identifier.wosid | 001004254500001 | - |
dc.citation.endPage | 2143.e22 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2127 | - |
dc.citation.title | Cell | - |
dc.citation.volume | 186 | - |
dc.contributor.affiliatedAuthor | Hur, Yun Ha | - |
dc.identifier.scopusid | 2-s2.0-85157992875 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.